Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. Genes Immun 2009;10:495-502.Kaiser R, Bijl M, Veeger NJ, Kluin-Nelemans HC, van der Meer J. Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. Genes ...
HH Van Boven,PH Reitsma,FR Rosendaal,... - 《Blood Coagulation & Fibrinolysis》 被引量: 238发表: 1995年 Factor V Leiden Gene Mutation and Thrombin Generation in Relation to the Development of Acute Stroke To determine the prevalence of the factor V Leiden gene mutation in relation to the ...
Factor V Leiden (FVL) is the most common monogenic disorder that causes activated protein C (APC) resistance, creating hyper-coagulation. The mutation shows an uneven geographic distribution, significantly high in European populations. The mutation is believed to have originated approximately 20 000 ye...
凝血因子Factor V是一种凝血过程中的蛋白因子,它位于内外源性凝血途径的交汇点,能够加速和促进凝血酶原的激活和凝血酶的生成。Factor V基因上的鸟嘌呤G突变为腺嘌呤A,造成第506上的谷氨酰胺被精氨酸替代,这样就形成了突变基因Factor V Leiden(FVL)。FVL会使凝血酶蛋白C(APC)的活性作用遭到抵抗,从而使血液的凝血功...
The objective of the study was to determine the prevalence of the factor V Leiden (FVL) mutation and its association with obstetric complications, blood loss during delivery, and venous thromboembolism (VTE). Study Design This was a prospective, observational, case-cohort study of 491 FVL carriers...
Factor V Leiden ...5 Coexisting thrombophilic disorders ...5 Circumstantial risk factors...6 Central venous catheters...
TheNetherlands4Towhomcorrespondenceshouldbeaddressedat:DepartmentofObstetrics,GynaecologyandReproductiveMedicine,LeidenUniversityMedicalCenter,Postbus9600,2300RCLeiden,TheNetherlands.E-mail:frederique@vandunne.tkBACKGROUND:FactorVLeiden(FVL,Arg506Gln)mutationmayfacilitateembryoimplantationandincreasefertilityandfecundity....
factor V to factor Vac, which decreases aPC anticoagulation activity, and tips the scale towards coagulation.[7]Decreased aPC activity, or increased aPC resistance, leads to increased coagulation, which contributes to the thromboembolic phenotype of factor V Leiden. The site for activated factor V ...
67 children with cancer were evaluated for the factor V Leiden mutation. One of 32 children with cancer and thrombosis, and none of 35 who had not experienced thrombotic problems, was found heterozygous for this mutation. We conclude that the factor V Leiden mutation does not play a ...
Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 1997; 89: 2817–2821. CAS PubMed Google Scholar van de Water NS, French JK, Lund M, Hyde TA, White HD, Browett PJ . Prevalence of factor V Leiden and prothrombin variant F202...