Kaiser R, Bijl M, Veeger NJ, Kluin-Nelemans HC, van der Meer J. Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. Genes Immun 2009; 10:495-502.Kaiser R, Barton JL, Chang M, et al. Factor V Leiden and thrombosis in patients with systemic...
Factor V Leiden ...5 Coexisting thrombophilic disorders ...5 Circumstantial risk factors...6 Central venous catheters...
Factor V Leiden mutation and PT 20210 mutation tests determine whether you have inherited a gene mutation that increases your risk of developing a harmful blood clot, including a deep venous thrombosis (DVT) or venous thromboembolism (VTE)
Factor V Leiden mutation is a rare anomaly, which is prone to increase the thrombotic incidents in those who have the abnormality compared to the normal po
The degree of associated bleeding worsens with lower residual factor levels, although the coinheritance of thrombophilic abnormalities (deficiencies of antithrombin, protein C, or protein S; Factor V Leiden; prothrombin gene mutation G20210A; and hyperhomocysteinemia) may occur and will moderate the ...
Factor VIIa, a vitamin K-dependent plasma serine protease, is the first enzyme in the coagulation cascade. The majority of this glycoprotein circulates as the inert zymogen (factor VII) with a concentration in pooled normal plasma of about 470 ng/ml (9.4 nmol/L)1. However, low levels of...
1. Factor V Leiden in an Urartian, dating back to 1000 BC. [J] . Alakoc YD, Aka PS, Egin Y, Clinical and applied thrombosis/hemostasis . 2010,第6期 机译:乌拉尔人时期的因子V莱顿,其历史可追溯到公元前1000年。 2. Factor V Leiden in an Urartian, Dating Back to 1000 BC [J] . ...
Van Deerlin, D.G. Leonard, K.A. Bauer Thrombosis in a patient with combined homozygosity for the factor V Leiden mutation and a mutation in the 3'-untranslated region of the prothrombin gene Blood Coagulation Fibrinolysis : Int. J. Haemostasis Thrombosis., 10 (2) (1999), pp. 107-110 ...
A reduction in the level of FIX via reduction of thrombin generation reduces TAFI activation and increases fibrinolysis, whereas persistence of FVa (as is the case with co-inheritance of factor V [FV] Leiden) leads to increased (persistent) thrombin production and TAFI activation, thereby inhibitin...
'Factor V-Leiden/Cambridge' or 'FV-L/C'), or other combinations thereof (all as compared to the mature sequence disclosed in Jenny et al, 1987, or to the amino acid sequence as present in Swissprot entry P12259, which both represent wild type human Factor V sequences; SEQ. ID. NO....