Clinical Significance:This test detects the factor V Leiden variant, the most common cause of inherited thrombophilia; it may be used to evaluate individuals with a strong personal or family history of venous thromboembolism (VTE) and inform treatment or preventive decisions [1]. Factor V Leiden r...
sensitive on-line laser-induced fluorescence detection enabled completion both the digestion and electrophoresis analysis procedures in less than 15 minutes for up to 96 samples, thus, genotyping of factor V Leiden mutation with this new protocol can be accomplished in a sensitive and high throughput...
METHOD VALIDATION FOR DETECTION OF FACTOR V LEIDEN MUTATION BY REAL TIME PCR AND RFLP ANALYSISCoagulation is the complex process by which blood forms clot. Disorders of the coagulation can lead to an increased risk of bleeding. Blood coagulation is under the control of anticoagulant protein present...
Myocardial infarction (MI) can be due to inherited thrombophilia caused by resistance to activated protein C resulting from factor V Leiden (FVL) mutation.The objectives of this study were to estimate the frequency of FVL mutation among MI cases in various populations and calculate the overall risk...
Factor V Leiden mutation is a common genetic risk factor for venous thrombosis. It has been documented in up to 65% of patients with unexplained venous thromboembolism. This genetic mutation is now known to be the most common inherited cause of activated protein C (APC) resistance. Recently, ...
Methods: Newborns from 22 pregnant women with thrombophilia (Factor V Leiden (FVL), n=16; anticardiolipin antibodies, n= 3; lupus anticoagulant, n=1; protein C deficiency, n=1; prothrombin G20210A mutation, n=1) were enrolled into the study. All women were treated with low-molecular-...
Idiopathic portal hypertension in a systemic sclerosis patient heterozygous for factor V Leiden mutation Here we present a rare case of systemic sclerosis (SSc) with idiopathic portal hypertension (IPH) having factor V Leiden mutation, a well-known genetic ris... M Ishii,Y Katada - 《Rheumatology...
So other genetic and social factors could not be neglected, because approximately 80% of pre with this mutation would be valu- able for future counseling regarding risk of throm 1 5). Our resultsupports a previously published work about the connection between factor V Leiden doi...
doi:10.1016/S0928-4257(01)00067-5FactorVLeidenmutationInflammatoryboweldiseaseBackground: the developmental mechanism of inflammatory bowel disease (IBD) in patients is unknown, but it may be influenced by different environmental and genetical factors. Aims of this study were: (1) to classify the ...
Testing The diagnosis of Factor V Leiden requires the APC resis- tance assay, a coagulation screening test, or DNA analysis of F5, the gene encoding Factor V, to identify the Leiden mutation, a specific G-to-A substitution at nucleotide 1691 that predicts a single-amino acid replacement (R...