Clinical Significance:This test detects the factor V Leiden variant, the most common cause of inherited thrombophilia; it may be used to evaluate individuals with a strong personal or family history of venous thromboembolism (VTE) and inform treatment or preventive decisions [1]. Factor V Leiden r...
sensitive on-line laser-induced fluorescence detection enabled completion both the digestion and electrophoresis analysis procedures in less than 15 minutes for up to 96 samples, thus, genotyping of factor V Leiden mutation with this new protocol can be accomplished in a sensitive and high throughput...
METHOD VALIDATION FOR DETECTION OF FACTOR V LEIDEN MUTATION BY REAL TIME PCR AND RFLP ANALYSISCoagulation is the complex process by which blood forms clot. Disorders of the coagulation can lead to an increased risk of bleeding. Blood coagulation is under the control of anticoagulant protein present...
Factor V Leiden mutation: the most commonly inherited risk factor for venous thromboembolism - retrospective analysis and follow-up after diagnosis of 238 ... MM Monga - 《Primary Care Update for Ob/gyns》 被引量: 6发表: 1999年 Factor v Leiden: Pathophysiology and clinical implications Factor ...
Myocardial infarction (MI) can be due to inherited thrombophilia caused by resistance to activated protein C resulting from factor V Leiden (FVL) mutation.The objectives of this study were to estimate the frequency of FVL mutation among MI cases in various populations and calculate the overall risk...
Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis were used to identify the FV Leiden G1691A mutation. The results of the present study showed that the incidence of blood clotting factor V Leiden mutation was found in 8 (16%) patients, from which 7 ...
Factor V Leiden (FVL) is the most common monogenic disorder that causes activated protein C (APC) resistance, creating hyper-coagulation. The mutation shows an uneven geographic distribution, significantly high in European populations. The mutation is believed to have originated approximately 20 000 ye...
OBJECTIVE: The aim of this prospective study was to find the association between the factor V Leiden mutation and adverse pregnancy outcomes. METHODS: This study is an analysis of a prospective observational study of the frequency of placenta-mediated complications of factor V Leiden mutation carriers...
Objective To investigate the relationship between factor Ⅴ Leiden mutation and cerebral venous thrombosis in China Methods 20 patients and 50 controls of Chinese origin were studied by polymerase chain reaction followed by MnlⅠrestriction enzyme analysis Results The PCR products of all the people super...
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