Coagulation factor XIII (FXIII) is a plasma circulating heterotetrameric pro-γ-transglutaminase, which plays an important role in the terminal phase of the clotting cascade by covalently cross-linking the pre-formed fibrin clot into an insoluble one, thereby protecting it from premature fibrinolysi...
Factor VII (FVII) is a vitamin-K dependent clotting factor that is crucial in triggering blood coagulation. Inherited deficiency of factor VII, which is an autosomal recessive disorder caused by mutations in the F7 gene, is the most common of the rare coagulation disorders. The clinical features...
The most common hereditary bleeding disorder arises from abnormalities in von Willebrand factor (VWF). VWF occurs in plasma as multimers of a 240,000 Da subunit, with molecular weights ranging from 1–20 million Da. The principal functions of VWF are to act as a carrier for ...
Multiple clotting factor deficiencies are rare and may arise either by the chance simultaneous occurrence of more than one hereditary single factor deficiency state or as a single inherited disorder with which two or more deficiencies are associated, e.g. combined factor VIII and factor V deficiency...
Modes of treatment, including the empiric use of corticosteroids and splenectomy, were discussed in light of current knowledge of pathogenesis of this unusual blood clotting disorder. This involves the interaction of amyloid fibrils and blood clotting factors. 展开 关键词: primary amyloidosis factor-X ...
Structural Analysis of N-Linked Sugar Chains of Human Blood Clotting Factor IX The structures of N-glycans of human blood clotting factor IX were studied. N-Glycans liberated by hydrazinolysis were N-acetylated and the reducing-end su... Y Makino,K Omichi,N Kuraya,... - 《Journal of Bioc...
The FXI activity levels were determined using a one-stage clotting assay (Siemens, Marburg, Germany), standardized using a homemade normal plasma pool. The reference interval, based on a locally performed reference range, was 70–150 IU/dl. The assay was performed using a BCS automated coagula...
Assessing the clotting function inevitably brings about dilution of plasma. With the existing techniques of thrombin generation (TG) measurement, dilution ... ED Smedt,R Wagenvoord,HC Hemker - 《Thrombosis & Haemostasis》 被引量: 95发表: 2009年 Cutaneous leishmaniasis: immune complex formation and...
clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.Want to thank TFD for its existence? Tell a friend about us, add a link to...
factor V and VIII deficiency, manifested by an autosomal-recessive bleeding disorder characterized by coordinate reduction of both clotting proteins.227These proteins form a cargo receptor that facilitates the transport of factors V and VIII, and presumably other proteins, from the ER to the Golgi....