Bleeding and thrombosis are related to contact of blood and its cellular components with the non-biologic surface of the extracorporeal circuit used that results in a massive inflammatory and clotting response. Factor XII deficiency is not associated with bleeding, but results in a significant ...
Legal Financial Encyclopedia Wikipedia Related to factor II:factor IIa ThesaurusAntonymsRelated WordsSynonymsLegend: Switch tonew thesaurus Noun1.factor II- a protein in blood plasma that is the inactive precursor of thrombin prothrombin clotting factor,coagulation factor- any of the factors in the bloo...
Christmas disease - a clotting disorder similar to hemophilia A but caused by a congenital deficiency of factor IX haemophilia B, hemophilia B bleeder's disease, haemophilia, hemophilia - congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to son Based ...
Although VWD is a defect in a soluble clotting factor, bleeding in patients with this disorder is more similar to that produced by a defect in platelet number or function. The bleeding manifestations tend to be more of the “oozing and bruising” variety affecting skin and mu...
ABBR: FSF Coagulation factor XIII, a clotting factor that is active in the intrinsic, extrinsic, and common pathways of coagulation and, when activated by thrombin, transforms monomeric fibrin to stable fibrin polymers. SYN: SEE: plasma transglutaminase SEE: blood coagulation ; SEE: coagulation ...
If you have aHUS, your doctor will need to monitor you closely for at least 12 months after stopping treatment for signs of worsening aHUS or problems related to a type of abnormal clotting and breakdown of your red blood cells called thrombotic microangiopathy (TMA). Symptoms or problems tha...
Factor VIII (FVIII) is an essential clotting factor. The lack of normal FVIII causes Hemophilia A, an inherited bleeding disorder. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the...
Although administration of clotting factor in prophylaxis has been shown to be beneficial for both hemophilia A and B, it is more commonly used with hemophilia A than hemophilia B. The reasons for this are unclear.[23] In children who are starting therapy for the first time or in persons wi...
Coagulation factor XIII (FXIII) is a plasma circulating heterotetrameric pro-γ-transglutaminase, which plays an important role in the terminal phase of the clotting cascade by covalently cross-linking the pre-formed fibrin clot into an insoluble one, thereby protecting it from premature fibrinolysis...
of a pharmaceutical composition disclosed herein to a subject in need thereof. In certain embodiments, the subject is at risk for, suspected of, exhibiting symptoms of, or diagnosed with a blood clotting disorder, e.g., wherein the subject is diagnosed with hemophilia A or acquired hemophilia....