PNH is a rare and severe blood disorder characterized by the destruction of red blood cells, known as intravascular hemolysis (IVH), and white blood cell and platelet activation that can cause thrombosis (blood clots) and result in organ damage and potentially premature death.1-3 Marc Dunoyer,...
Accordingly, a bleeding disorder arises when there is a deficiency of protein C inhibitor. Factor V is a single-chain glycoprotein of approximately 340 000 mol. wt., and it circulates at a concentration of about 7 μg/mL in the blood.26 It is activated by thrombin to form factor Va, ...
Blood-device interaction Mechanical Circulatory and Respiratory Support Book2018,Mechanical Circulatory and Respiratory Support Michael J.Simmonds, ...JarodHorobin Explore book Von Willebrand Factor (vWF) Von Willebrand factoris a large heterogeneous multimericglycoproteinwith molecular weight ranging up to...
Given its multiple homeostatic functions, we hypothesise that ERG may have an anti-thrombotic effect in EC, thus protecting blood vessels from spontaneous clot formation. In this study, we show that inducible chronic endothelial-specific deletion of ERG in adult mice leads to systemic coagulopathy wi...
ABSTRACT Factor VII deficiency is a rare bleeding disorder in which prema- ture death may occur from severe bleeding. Up to now, our scientific knowledge ... G Mariani,FH Herrmann,F Bernardi,... - 《Blood》 被引量: 95发表: 2000年 International Factor VII Deficiency study Group: Thrombosis...
Fresh anticoagulated whole blood (EDTA) was collected and diluted with an equal volume of tissue diluent. The separation solution was then added to the centrifuge tube at 2× the blood volume. The diluted blood was then spread on top of the separation liquid level, and the interface between ...
The following is heavily based on Trueblood et al., 1996 and references therein. Displacement of atoms from their mean position in a crystal structure diminishes the scattered X-ray intensity. The displacement may be the result of temperature-dependent atomic vibrations or static disorder in a cry...
Structural Analysis of N-Linked Sugar Chains of Human Blood Clotting Factor IX The structures of N-glycans of human blood clotting factor IX were studied. N-Glycans liberated by hydrazinolysis were N-acetylated and the reducing-end su... Y Makino,K Omichi,N Kuraya,... - 《Journal of Bioc...
Compared to HFHS-fed wildtype mice, HNF4α HET mice had down-regulation of lipid catabolic genes, induction of lipogenic genes, and increased hepatic and blood levels of lipids, whereas HNF4α KO mice had fatty liver but mild hypolipidemia, down-regulation of lipid-efflux genes, and induction...
Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (2000) FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Blood 95(5):1788–1796 PubMed CAS Google Scholar Yamamoto K...