Fabp4 -Cre转基因具有5.4 kbp的小鼠Fabp4启动子,指导Cre重组酶的表达。这些FABP4-Cre转基因小鼠是一个可用于删除棕色和白色脂肪组织中floxed序列的Cre-lox工具。与C57BL/6NJ近交系小鼠进行多代杂交,采用标记辅助、快速同源方法获得了该C57BL/6NJ同源品系。
Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosisArid5bObesityDietSteatosisMice with global deletion of Arid5b expression are lean and resistant to diet-induced obesity, and Arid5b is required for adipogenesis in a variety of in vitro models. To ...
et al. Fabp4-Cre-mediated deletion of the miRNA-processing enzyme Dicer causes mouse embryonic lethality. Acta Diabetol 50, 823–824 (2013). https://doi.org/10.1007/s00592-011-0335-4 Download citation Received23 July 2011 Accepted17 September 2011 Published08 October 2011 Issue DateOctober ...
The Sirt6-knockout mice generated by the Fabp4-Cre line (Sirt6f/f:Fabp4-Cre) had a significant increase in both body weight and fat mass and exhibited glucose intolerance and insulin resistance as compared with the control wild-type mice. At the molecular levels, the Sirt6f/f:Fabp4-...
Since the Fabp4 Cre driver has Discussion Mice with a global knockout of Arid5b have a high rate of neonatal mortality, and both male and female adults are lean and resistant to diet-induced obesity (Whitson et al., 2003). By contrast, FSKO mice survived normally as neonates, and were...
FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance 来自 掌桥科研 喜欢 0 阅读量: 44 作者:Nuotio-Antar Alli M.,P Naravat,M Li,S Michael,M Mahmoud,G Sarah,Z Fang,L Chan ...
什么是cre鼠?cre鼠就是我们常用的带有不同的cre酶的工具鼠统称,可用于繁育交配,比如说B6.129P2-Lyz2 tm1(cre)lfo/NJU, 这种就是我们的带有骨髓细胞特异表达cre酶的模型,还有很多很多在不同组织表达的酶的模型,可以根据自己的实验需求来安排。 FabP4-Cre(AP2-cre)小鼠介绍 ...
(2010) Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research. FEBS Lett. 584 , 1054–1058Martens K, Bottelbergs A, Baes M. Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: ...
In conclusion, our data suggest that the function of SIRT6 in the Fabp4-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis. 展开 关键词: Sirt6 adipocyte Fabp4-Cre Adipoq-Cre conditional gene knockout ...
Fabp 4-Cre-mediated Sirt 6 deletion impairs adipose tissue function 1 and metabolic homeostasis in mice 2 Running title : Sirt 6 function in adipose tissue 3 来自 Semantic Scholar 喜欢 0 阅读量: 3 作者:X Xiong,C Zhang,Y Zhang,R Fan,X Qian,X Dong,C Dong ...