Here, we found that the application of low shear stress (LSS; 2鈥塪yn/cm2 ) to human breast carcinoma cells (MDA-MB-231) resulted in increased anoikis resistance when tumor cells were grown under anchorage-independent conditions. Caveolin-1 (Cav-1), the major component of plasma membrane ...
Membrane-proximal BCR signaling also involves the activation of the p85α/p110δ heterodimeric isoform of phosphatidylinositol (PI) 3 kinase (PI3K), which rep- resents a key component of BCR signaling cascades. Although it is not completely clear how PI3K is recruited to the membrane-proximal ...
The canonical NF-κB signaling pathway is a critical component of the proinflammatory astrocytic response induced by cuprizone [181]. The canonical NF-κB pathway may be activated by a TrkB ligand [180] but also by other cytokines, such as Tumor necrosis factor (TNF) [182]. In mice ...
Considering that FADD is involved in CD95 and TRAIL-R signaling as an adaptor molecule, in this context, it is conceivable that any modification in this pivotal signaling component may interfere with the transduction of DR signaling. Indeed, extrinsic apoptosis signaling was shown to be impaired ...
Mechanism of inhibition of the extrinsic tenase complex. To understand the molecular mecha- nism, the effect of exactin on ETC was examined using various assays in which each component of the ETC was removed sequentially to evaluate the role of individual components in the susceptibility of ...
Multiple kinetic constants are presented in some cases to indicate the results obtained with a different preparation of at least one macromolecular component. RESULTS Kinetics of Inhibition by Active Site-directed Ligands PAB is a well characterized reversible inhibitor of arginine-specific serine ...
Among the factors mediating the pro-aging effects of aged plasma in the DG niche are CCL-11—an eosinophil-recruiting chemokine—and β2M—a component of type 1 major histocompatibility complex). Both increase with age and disturb NSPC proliferation and neurogenesis in vivo and in vitro, ...