Here, we found that the application of low shear stress (LSS; 2鈥塪yn/cm2 ) to human breast carcinoma cells (MDA-MB-231) resulted in increased anoikis resistance when tumor cells were grown under anchorage-independent conditions. Caveolin-1 (Cav-1), the major component of plasma membrane ...
there was a very large degree of heterogeneity for both treatment groups, with some patients showing up to 50% improvement in FEV1and others showing a decline in lung function with a 30% decrease in FEV1(Figure 28.6). This interindividual variability, a component of clinical trials that is sel...
Membrane-proximal BCR signaling also involves the activation of the p85α/p110δ heterodimeric isoform of phosphatidylinositol (PI) 3 kinase (PI3K), which rep- resents a key component of BCR signaling cascades. Although it is not completely clear how PI3K is recruited to the membrane-proximal ...
1 Current clinical care for GBMs is largely palliative, and the poor response of GBMs to chemotherapy is a major barrier for successful therapy.1,2 One key component promoting temozolomide (TMZ, the chemotherapeutic standard of care) resistance is the DNA damage response (DDR) pathway in tumor...
Mechanism of inhibition of the extrinsic tenase complex. To understand the molecular mecha- nism, the effect of exactin on ETC was examined using various assays in which each component of the ETC was removed sequentially to evaluate the role of individual components in the susceptibility of ...
Anothercandidate is Sec16, a component of the tER sites in yeast,Current Opinion in Cell Biology 2005, 17:362–368 www.sciencedirect.com fl y and human. Depletion or mutation of Sec16 comple-tely disorganizes tER sites, with failure to recruit Sec23(Ben Glick, personal communication; and ...
The canonical NF-κB signaling pathway is a critical component of the proinflammatory astrocytic response induced by cuprizone [181]. The canonical NF-κB pathway may be activated by a TrkB ligand [180] but also by other cytokines, such as Tumor necrosis factor (TNF) [182]. In mice ...
Furthermore, the mitochondrial component of the AKF-D52-induced apoptosis mechanism involves a reduction in mitochondrial membrane potential and regulation in B cell lymphoma-2 family protein expression. Moreover, AKF-D52 activates the extrinsic pathway through up-regulated expression of death receptor ...