Extracellular vesicle–matrix interactions Extracellular vesicles (EVs) are lipid-bound nanoscale mediators of intercellular communication. This Review discusses EVs in the context of the extracellular matrix, highlighting how the understanding of their interactions inspires materials design to control the rel...
The extracellular matrix (ECM) harbours various signals to control cellular functions and the materiality of tissues. Most efforts to synthetically reconstitute the matrix by biomaterial design have focused on decoupling cell-secreted and polymer-based c
OMV: outer-membrane vesicle; OIMV: outer-inner membrane vesicle; CMV: cytoplasmic membrane vesicles. Types and general functions of MVs Different MVs have different structures and compositions depending on the diverse routes of the formation of MVs. OMVs are bilayered lipid membrane nanostructures 20...
L. Exosomes and other extracellular vesicles in host-pathogen interactions. EMBO Rep. 16, 24–43 (2015). CAS PubMed Google Scholar Deatherage, B. L. & Cookson, B. T. Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life. ...
Intraluminal vesicle JAK: Janus kinase MAPK: Mitogen-activated protein kinase MDR: Multidrug resistance proteins MDSC: Myeloid-derived suppressor cells MEK: MAPK/ERK Kinase MICA: MHC class 1 related chain ligand A MIF: Migration inhibitory factor ...
Interestingly, differential extracellular matrix-NPC interactions resulted in decreased protein expression of Cx43, along with diminished levels of Cx40, Cx45, Cx47, and increased Cx36 expression. These processes were linked to decreased neurogenesis (Imbeault et al., 2009). Lastly, Cx43 expression...
(G-EGT). This biosensor’s design incorporates an advanced antifouling strategy, utilizing a dual-blocking process that effectively reduces interference from the complex biological matrix of serum, enhancing detection sensitivity. With a limit of detection at the attogram level (447 ag/mL). The ...
Extracellular matrix EV: Extracellular vesicle HMGCR: 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase HSC: Hepatic stellate cell IL: Interleukin IR: Ionizing radiation KLF: Krüppel-like factor LPS: Lipopolysaccharide mRNA: Messenger RNA miRNA: ...
There is a lack of broad and detailed understanding of extracellular vesicle functions and a need for the development of new and personalized extracellular vesicle-based therapies to treat different cardiovascular diseases. Introduction Cardiovascular diseases (CVDs) are the leading cause of death, account...
Proteomic analysis of the vesicle fractions of EVs (based on their sizes) showed the presence of some common and some unique proteins. These proteins mediate distinct effects like transport, cellular response, effector process on maternal communication during early gestation. This study also recognizes...