Extracellular vesicle–matrix interactions Extracellular vesicles (EVs) are lipid-bound nanoscale mediators of intercellular communication. This Review discusses EVs in the context of the extracellular matrix,
The extracellular matrix (ECM) harbours various signals to control cellular functions and the materiality of tissues. Most efforts to synthetically reconstitute the matrix by biomaterial design have focused on decoupling cell-secreted and polymer-based cues. Cells package molecules into nanoscale lipid-me...
OMV: outer-membrane vesicle; OIMV: outer-inner membrane vesicle; CMV: cytoplasmic membrane vesicles. Types and general functions of MVs Different MVs have different structures and compositions depending on the diverse routes of the formation of MVs. OMVs are bilayered lipid membrane nanostructures 20...
Extracellular vesicle–matrix interactions Article 17 March 2023 Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity Article Open access 16 December 2021 References Karamanos, N. K. et al. A guide to the composition and functions of the extrace...
Extracellular vesicle–matrix interactions 2023, Nature Reviews Materials Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases 2023, Journal of Extracellular Vesicles Recent advances in developing active targeting and multi-functional drug deli...
Intraluminal vesicle JAK: Janus kinase MAPK: Mitogen-activated protein kinase MDR: Multidrug resistance proteins MDSC: Myeloid-derived suppressor cells MEK: MAPK/ERK Kinase MICA: MHC class 1 related chain ligand A MIF: Migration inhibitory factor ...
Extracellular vesicles (EVs) have emerged as important players in intercellular signaling and tumor-stroma interactions. Cells generate EVs to communicate with other cells at local or distant sites and modify the behavior of these target cells. EVs are encapsulated with a phospholipid membrane and can...
Extracellular matrix EV: Extracellular vesicle HMGCR: 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase HSC: Hepatic stellate cell IL: Interleukin IR: Ionizing radiation KLF: Krüppel-like factor LPS: Lipopolysaccharide mRNA: Messenger RNA miRNA: ...
1) whether there are more direct interactions between ECs and other bone cells; 2) what other important protein factors are involved; 3) the function and mechanism of EVs derived from ECs; 4) what differences exist between H-type ECs and L-type ECs in communication with other bone cells; ...
A recent approach using extracellular-matrix-simulating hydrogels showed that EVs were superior to liposomes in escaping stress-relaxing environments60, indicating the influence of vesicle surface proteins. Immune responses and potential toxicity Owing to the occurrence of adverse immunological reactions to ...