In this Review, we discuss various aspects of EV-matrix interactions. Cells receive feedback from the ECM and leverage intracellular processes to control the biogenesis of EVs. Once secreted, various biomolecular and biophysical factors determine whether EVs are locally incorporated into the matrix or...
Extracellular vesicle–matrix interactions Extracellular vesicles (EVs) are lipid-bound nanoscale mediators of intercellular communication. This Review discusses EVs in the context of the extracellular matrix, highlighting how the understanding of their interactions inspires materials design to control the rel...
den and colleagues were the first to report a positive correlation between the expression of genes associated with vesicle shedding and drug resistance in a large panel of different cancer cell lines [91]. Furthermore, using a breast cancer cell line, they showed by fluorescence microscopy and fl...
injury and stress result in altered communication patterns in the tissue microenvironment. When left unchecked, EV-mediated interactions between stromal, immune, and parenchymal cells lead to the development of disease states
Therefore, we have uniformly used the generic term “extracellular vesicle” (EV) in this review [2]. Herein, we provide a summary of the intercellular communication that EVs mediate in vascular diseases, mainly referring to the relevant literature published in the last five years. We discuss ...
4.Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells. 细胞-基质相互作用调节间充质基质细胞的功能性细胞外囊泡分泌。 [ACS Nano] PMID:34677951 摘要:细胞外囊泡 (EV) 是细胞分泌的颗粒,具有广泛的潜力,通过将货物运送到程序靶细胞来治疗组织损伤。然而,由于...
interactions. Inhibition of HIV-1 infection is associated with the presence in EVs of several proteins and metabolites. Our findings demonstrate that the protective effect ofLactobacillusagainst HIV-1 is, in part, mediated by EVs released by these symbiotic bacteria. If confirmed in vivo, this ...
and cellular function of the major extracellular vesicle subsets of exosomes, microvesicles, apoptotic bodies and large oncosomes. Abbreviations: EV, extracellular vesicles; ESCRT endosomal sorting complex required for transport; ILV, intraluminal vesicle; MVB, multivesicular body. Figure was created with ...
Tumor-derived Extracellular Vesicle Stimulation of Primary Rat Prostate Fibroblasts Primary rat mesenchymal cell cultures, here referred to as fibroblasts, were established and maintained according to Tuxhornet al.60. Rat ventral prostate tissues were cut into small tissue pieces and washed with DMEM (...
Extracellular matrix (ECM) is a kind of connective tissue in the cell microenvironment, which is of great significance to tissue development. ECM in muscle fiber niche consists of three layers: the epimysium, the perimysium, and the endomysium (basal lamina). These three layers of connective...