目的:检测三叶因子3(trefoil factor 3,TFF3)、诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)、细胞外调节蛋白激酶2(extracellularregulated protein kinases 2,ERK2)在胃癌前病变及胃癌的表达,观察其与幽门螺杆菌(Helicobacter pylori,Hp)感染的相关性,探讨TFF3、iNOS、ERK2的表达与胃癌发生、发展的关系。
1) extracellular signal regulated kinases/ mitogen-activated protein kinases 细胞外调节激酶-丝裂原活化蛋白激酶2) MAPK-ERK 丝裂原活化蛋白激酶-细胞外信号调节激酶 1. Objective To evaluate whether PD 98059,suppressing MAPK-ERK signaling pathway,can change the sensitivity of esophageal carcinoma cells to...
Epidermal growth factor activates extracellular signal-regulated protein kinases (ERK) in freshly isolated porcine granulosa cells We investigated the ability of EGF to stimulate the phosphorylation (i.e. activation) of extracellular signal-regulated kinases (ERKs) in freshly isolated ... BA Keel,JS ...
Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signalregulated kinase and ornithine decarboxylase. Pathobiology 2000; 68: 113–23. Article PubMed CAS Google Scholar Denkert S, Siegert A, Leclere A et al. An inhibitor of stress-activated MAP-kinases ...
extracellular signal-regulated kinases MAPK mitogen-activated protein kinase MoDC monocyte-derived dendritic cell PDTC pyrrolidine dithiocarbamate SAPK/JNK: stress-activated protein kinase/c-jun N-terminal kinases It is well known that, although dendritic cells (DC) are the most potent antigen-presenting...
Our studies showed that RD-1-encoded secretory protein ESAT-6 is involved in modulation of the mitogen-activated protein (MAP) kinase-signaling pathway inside the macrophage. ESAT-6 induced phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) in the cytoplasm but not in the nu...
Functional role of extracellular signal-regulated protein kinases in gastric acid secretion. Presents a study which examined the function and physiological role of the extracellular signal-regulated protein kinases (ERK) pathway in the process of gastric acid secretion. What is gastric acid secretion; ...
We report herein that senescence-associated phosphorylated extracellular signal-regulated protein kinases 1 and 2 (SA-pErk1/2) enhanced p21(Sdi1) transcription by phosphorylating Sp1 on Ser(59) downstream of protein kinase C (PKC) alpha. Reactive oxygen species (ROS), which was increased in ...
Pb~(2+) Induced IL-8 Gene Expression by Extracellular Signal-Regulated Kinases and the Transcription Factor, Activator Protein 1, in Human Gastric Carcinom... Pb2+ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human ga...