N. ( 2002 ) The role of extracellular signal regulated kinase in cognitive and motor deficits following experimental traumatic brain injury . Neurosci. 114 , 755 – 767 .Dash PK,Mach SA,Moore AN.The role of extracelluar signal-regulated kinase in cognitive and motor deficits following ...
With regard to the liver, activation of Notch signal- ling in hepatocytes was previously shown to induce liver fibrosis in nonalcoholic fatty liver disease62. Our RNA-sequencing (RNA-seq) analyses indicated that in contrast to S3 EVs, S2 EVs impose meta- bolic stress on HepG2 cells. The ...
Interestingly, DCN and LUM were strongly upregulated, on mRNA and protein levels, in floating spheroid cultures of SK-N-SH NB cells grown in serum-free (SF) neural stem cell medium to allow for enrichment of population of cancer stem cell-like cells (CSCLC), as compared with adherent ...
In vitro investigations of CRC cells (HCT116, HT29) revealed that NETs did not affect their proliferation but did promote the migration of CRC cells mediated by neutrophil elastase (NE) released during NETosis to increase extracellular signal-regulated kinase (ERK) activity. In vivo experiments ...
2.5. PART II: Detecting the Global Cell Response Induced by EVs and Their Application as Antiproliferative Signal Carriers Co-Culture Results: Subcellular Response of the Co-Cultured Cell Line A graphical description of the co-culture set-up between the Caco-2 adherent cells/U937 floating cells is...
Tian Y, Zhang M, Heng P, Hou H, Wang B. Computational Investigations on Reaction Mechanisms of the Covalent Inhibitors Ponatinib and Analogs Targeting the Extracellular Signal-Regulated Kinases.International Journal of Molecular Sciences. 2023; 24(20):15223. https://doi.org/10.3390/ijms242015223 ...
EVs have been hypothesized to be regulated by Cav-1, a well-known structural protein of caveolae [38]. Cav-1 plays a critical role in Cav-1-mediated signal transduction through the Caveolin-Scaffolding-Domain (CSD) [39] that interacts with a CSD-interacting motif (CIM) among the partner ...
LaMarca, H.L.; Dash, P.R.; Vishnuthevan, K.; Harvey, E.; Sullivan, D.E.; Morris, C.A.; Whitley, G.S. Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases. ...
Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epithelial-myofibroblast transdifferentiation. Nephrol. ...