Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet. 2012; 8 :e1002707.Zou F., Chai H. S., Younkin C. S., et al. Brain expression genome-wide association study (eGWAS) identifies human disease-associat...
We executed genome-wide association scans for these traits and found peak lod scores between 3.68 and 59.1. The most highly heritable traits were markedly enriched in Gene Ontology descriptors for response to unfolded protein (chaperonins and heat shock proteins), regulation of progression through the...
对研究一的5个共表达基因模块进行表达全基因组关联分析(expression genome-wide association study,eGWAS),将模块特征值作为数量性状.结果发现,GO和KEGG通路分析在埋植... 赵晨晨 - 内蒙古农业大学 被引量: 0发表: 2021年 Identification of potential mechanism and hub genes for neuropathic pain by expression-base...
The Manhattan plots of genome-wide association signals with (a) DTC and (b) PTC for stage 1. The x-axis represents the SNP markers on each chromosome. The y-axis shows the À log10 P-value (logistic regression). The red horizontal line represents the genome-wide significance threshold ...
Genome-wide association studies (GWAS) have achieved great success identifying common genetic variants associated with common human diseases. However, to date, the massive amounts of data generated from GWAS have not been maximally leveraged and integrated with other types of data to identify ...
To determine whether genetic predisposition to endometriosis varies depending on ethnicity and in association with expression quantitative trait loci (eQTL) in a Taiwanese population. We conducted a genome-wide association study (GWAS) and replicated it
Towards these goals, we have integrated relevant high dimensional data from various sources, such as genome-wide expression data (microarray), protein-protein interaction (PPI) data and results from genome-wide association studies (GWAS) in order to define sub-network elements that connect some of...
Over the past decade, several genome-wide association studies (GWAS) have uncovered multiple single-nucleotide polymorphisms (SNPs) associated with resistance to pathogenic fungi in soybean populations3,4,5,6,7,8,9. Nevertheless, GWAS often fail to accurately pinpoint the causative genes10. GWAS ...
Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways. Mult Scler J. 2017; 23(2):205-... Guiyou,Zhang,Fang,... 被引量: 0发表: 0年 Global analyses of gene expression in early experimental osteoarthritis ObjectiveTo analyze gen...
M. et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat. Genet. 49, 256–261 (2017). Article PubMed PubMed Central CAS Google Scholar Download references Acknowledgements This work was funded by Open Targets grant OTAR040...