we asked whether the genetic interaction with sex in the corresponding GWAS was nominally significant for the considered trait for the sites that were most significantly associated with the trait at the locus. There were 14 of 23 sex-specific risk proteins (61%) with suggestive evidence ...
While no anti-HA signal could be observed for constructs expressing the single AMP novispirin as well as untagged CXCL9 or the large constructs combining 6 or 9 different AMPs, (Fig. 2d), all other transplastomic lines showed bands corresponding to the expected size of the respective AMPs ...
Semiquantitative RT-PCR analysis was performed for genes that showed a weak signal by RT-PCR/Southern blot or to analyze differentially spliced transcripts [8]. Gene-specific primers were designed into the open reading frame of the cDNA sequence and are described in Table1. SMART cDNAs were ge...
sample size was not adequate for testing gene expression changes following RE for each of the four sex (male/female) and time (4 h & 24 h post exercise) specific conditions (n = 2, for each of the four groups). As
5). Brassinosteroids (BRs) are a key promoting signal for procambial division during primary growth [7]. Among 17 BR-related DEGs (Fig. 5), 10 transcripts encoding LRR receptor-like serine/threonine-protein kinase (RPK) were upregulated in UG3Y. The expression of F01_transcript_32940 ...
Densitometric analysis of each protein on the western blot was performed to quantify signal intensities using Image J software, with the loading control normalized to 1. Statistical Analysis At least five biological replicates were used for each analysis. All results are presented as the means ± ...
47 In the absence of PDE5, the cGMP elimination route via export may have even more impact in these cells for signal termination under conditions of enhanced cGMP formation. Another interesting aspect, in which the MRP5/cGMP elimination pathway may be involved, is the control of cardiac ...
The signal units for microarray are the intensities before the log base 2 scale transform and the asterisk and caret signs for microarray are the p values after Bonferroni correction. Full size image Discussion This study presents the first global gene expression profiling of the hepatic APR in ...
These findings for the first time demonstrate that TNFAIP8 is one of critical components of a signal transduction pathway that links mesangial cell proliferation to diabetic renal injury. Pharmacological targeting of this pathway at multiple levels may provide a novel approach to treatment of diabetic...
We then asked whether PEP and PP agree at a more broad scale, by testing whether the 327 coordinately evolving modules identified in a recent PP study6 showed increased PEP signal as well. We found significant (permutation p = 2.9 × 10−47; see Methods) enrichment for PEP cor...