DNA methylation contributes to the regulation of sclerostin expression in human osteocytes.OSTEOBLASTSOSTEOCYTESPROMOTERDNA METHYLATIONSCLEROSTINSclerostin, encoded by the SOST gene, is a potent inhibitor of bon
since the down-regulation of sclerostin was thought to be a mandatory step in the anabolic response to loading6. However, recently Morseet al. showed that young growing 10 week oldSost KOmice and strain-matched wild-type C57BL/6 mice had a similar response to ...
Dysregulated activation or repression of the promoters that drive the expression of CIITA is associated with various diseases, including infection with various pathogens, autoimmune and inflammatory diseases, and the development of tumours of various origins. Detailed knowledge of the regulation and dysregul...
In contrast, the Ptre-RbohF1 and Ptre-RbohF2 genes exhibited only the transient upregulation at the early stage of senescence. In an in vitro study, the ability of protein kinases Ptre-SnRK2.6a and Ptre-SnRK2.6b to phosphorylate the N-terminal regions of Ptre-RbohD1 and Ptre-RbohF2 ...
Regulation of alpha 2-macroglobulin gene expression by interleukin-6. Ann N Y Acad Sci 1994;737:308-23.Horn F, Wegenka UM, Lutticken C et al. Regulation of alpha 2-macroglobulin gene expression by interleukin-6. Ann N Y Acad Sci 1994; 737:308–323....
of their unique physiology. Birds have high metabolic rates and demand substantial energy reserves for flight, reproduction, and maintaining high body temperature19,20. Therefore, by investigating the regulation of mTOR pathway in birds, we not only gain insights into the fundamental mechanisms ...
3B), indicating that the regulation of telomeres by TGFβ is solely mediated through changes in splicing [29]. If a gene set is regulated by both expression and splicing (shared regulation), the enrichment score for the splicing and expression-based enrichment analysis is expected to be similar...
In this study, the transcriptome was used to illustrate the mechanisms of gene expression regulation in the somatic embryogenesis of tea plants. The number of DEGs for the (IS intermediate stage)_PS (preliminary stage), ES (embryoid stage)_IS and ES_PS stages were 109, 2848 and 1697, ...
Therefore, QS signaling systems serve as an alternative bio-element resource for developing novel manipulation or evaluation techniques of gene expression and regulation29,30,31,32. In this study, we aim to construct a sensitive visualization reporter system based on Gram-negative bacterial AHL QS (...
mRNA gene regulation tail-interacting protein of 47 kDa trophoblasts Adequate placental transport of fatty acids to the fetus is crucial for normal fetal development and growth. Long-chain polyunsaturated fatty acids (LCPUFAs) are important as cell membrane components as well as precursors of eicosan...