Sclerostin inhibits Wnt signalling and can also inhibit downstream effects of BMP such as alkaline phosphatase (ALP) activity and matrix mineralisation in vitro. The regulation of sclerostin or SOST, the gene encoding sclerostin, is not completely clear. Therefore, we investigated a possible feedback...
Together with previous literature, these new findings indicate that Sost/sclerostinregulation is complex and requires coordination of multiple mechanisms.Summary This review summarizes the current knowledge on the epigenetic regulation of Sost/sclerostin expression and discusses future research needed to ...
In this study, the transcriptome was used to illustrate the mechanisms of gene expression regulation in the somatic embryogenesis of tea plants. The number of DEGs for the (IS intermediate stage)_PS (preliminary stage), ES (embryoid stage)_IS and ES_PS stages were 109, 2848 and 1697, ...
since the down-regulation of sclerostin was thought to be a mandatory step in the anabolic response to loading6. However, recently Morseet al. showed that young growing 10 week oldSost KOmice and strain-matched wild-type C57BL/6 mice had a similar response to ...
extreme breeds, highlighting differences in the regulation of endometrial angiogenesis, nutrient transport and energy metabolism. We identified DEGs that showed high correlations with indicators of fetal maturation, such as ponderal index at D90 and fetal blood fructose level and placental weight at D110...
Various family members have been found to bind tumour suppressors such as p53, BRCA1 (breast cancer 1, early onset) and retinoblastoma protein [34, 43–45], supportive of roles in cell cycle regulation, DNA repair and apoptosis. Interactions with a range of transcription factors and signalling...
Microarray analysis is a powerful technique to study the relative gene expression of thousands of transcripts in one single experiment. Recently, researchers have used this technique to more comprehensively increase knowledge about the cellular and molecular changes seen in OA5, 6, 7, 8, 9, 10, ...
Digital expression was obtained using RNA samples from organs at different development stages and under different stress conditions. qPCR validated the digital expression data for a selection of 23 genes with high or low expression levels. Comparative gene expression analyses between the different tissues...
lncRNAs are known to regulate the expression of protein-coding genes through cis-acting or trans-acting regulation mechanisms18,19,20,21. As expected for regulatory molecules, lncRNAs tend to be expressed at lower level and display higher tissue specificity than protein-coding genes22,23. Although...
Using RT-qPCR, we found that the relative gene expression of targeted mRNAs correlated with our PANTHER and IPA results with upregulation of the p38 MAP kinase pathway (MAPK14 pathway) and the downregulation of SMAD4, ERK1 (MAPK3), ephrin signaling, ID1 signaling and MAPK3 (Fig. 3). ...