What is the main finding and its importance? Resting content of proteins in skeletal muscle involved in triglyceride hydrolysis and mitochondrial lipid transport are more strongly associated with peak fat oxidation rates than proteins related to lipid transport, or hydrolysis in adipose tissue. Whilst ...
Since studies of energy coupling and transport kinetics are complicated in vivo, we purified the major lysine transporter (Lyp1) of yeast and reconstituted the protein into lipid vesicles. We show that the Michaelis constant (KM) of transport from out-to-in is well in the millimolar range and...
Additionally, since receptors are often localized in lipid rafts with specific lipid and protein compositions, the possibility that conserved TM regions may have evolved in part due to raft composition should also be considered. Statistical Significance of the Results Reported Above The statistical ...
and Flux AnalysisIsotopomics Applications in Plant, Animal, and Human MetabolismsLifestyle Interventions: A ChallengingTherapeutic Strategy for Metabolic SyndromeLipid Metabolism in CancerMetabolic Flux AnalysisMetabolic Profiles in Diseases: From Diagnosis to Characterization and Clinical Management Volume 2...
We also described how the accumulation of lipid droplets in cancer cells is the manifestation of defective OxPhos [83]. Although fatty acids cannot be used as a fuel in tumor cells with defective OxPhos, they can enhance glucose and glutamine fermentation through a range of mechanisms [83,156,...