[6,7,39]. In vivo, migrasome-like structures were found in various organs such as the lungs, eyes, and intestines [6], and even in postmortem brain tissue of stroke patients [40]. Migrasomes also been isolated from body fluid, such as serum and urine [41,42]. Before leaving the ...
Fluorescent-labelling of AT-MSC-Exosomes was employed to track their cellular uptake under conditions of amyloid-related toxicity Results : ERG responses in rat eyes treated with AT-MSC-Exosomes prior to administration of toxic fibrillar Aβ42 assemblies were nearly intact compared to controls. The ...
MSC-Exos to be used in clinical trials must be produced under the GMP-grade condition in which the cell culture environment, cultivation system, dissipation enzyme, and culture medium are strictly monitored using GMP standards. MSC-Exos need to be purified and characterized for physical structure ...
MSC-Exos to be used in clinical trials must be produced under the GMP-grade condition in which the cell culture environment, cultivation system, dissipation enzyme, and culture medium are strictly monitored using GMP standards. MSC-Exos need to be purified and characterized for physical structure a...
and then they were characterized by a nanoparticle tracking analysis and transmission electron microscopy. In a murine model of corneal epithelial wounds, these exosomes were topically applied to evaluate their healing efficacy. The results demonstrated that the exosome-treated eyes showed significantly enh...
and found that their average size was 143.8 ± 1.1 nm, which was smaller than the exosomes from theL. fermentumKCTC 3112 strain. In addition, HY7302-derived exosomes significantly reduced the levels of genes encoding pro-inflammatory cytokines, includinginterleukin (IL)-20,IL-8,IL-6, andIL-1...
eyes and alleviate ongoing inflammation in ocular tissues by modulating the phenotype and function of all immune cells that play pathogenic roles in the development and progression of inflammatory eye diseases. MSC-Exos, due to their nano-sized dimension and lipid envelope, easily bypass all barriers...
Detrimental immune response has a prominent role in the development and progression of neuroinflammatory, neurodegenerative, and retinal diseases [1]. Injuries and the invasion of microbial pathogens in the eyes and central nervous system elicit a strong immune response, which induces damage to the blo...
Similarly, differentiation of these cells into keratocytes was seen in the rabbit cornea 12 weeks after transplantation with the synthesis of collagens type I and VI [105]. Likewise, transplantation of MSCs derived from dental pulp into rat’s eyes induced the production of an extracellular ...
These products can damage the maternal liver, kidney, eyes, brain, blood vessels, and lungs, placing the woman in mortal danger due to potential multiorgan failure. Various humoral factors and modifiers in the peripheral blood have been reported to underlie the pathology of PE, and the clinical...