It is worth noting that, in addition to RNA, exosomes contain other potential cargos that could be used as biomarkers, such as proteins including membrane proteins, lipids, and metabolites. Immuno-pulldowns can be designed in biofluids to enrich or deplete tissue-specific exosomes based on surfac...
However, there are risks associated with it as well, like immunogenicity and reversion to virulence. Therefore, the relentless search for alternative nanoparticles for gene delivery has led to the utilization of exosomes as a viable candidate. The similar mechanism of actions for gene transfection ...
ginseng-derived exosomes demonstrated effective penetration across closely spaced epithelial cells, such as C6 glioma cells and brain capillary endothelial cells (BCECs). The research indicated that ginseng-derived exosome-like nanoparticles (GENs) may serve as prospective agents to impede glioma progressio...
When compared to synthetic nanoparticles, exosomes are considered an optimal drug delivery system, as they encompass many exceptional features: remarkable biocompatibility and stability, minimal immunogenicity and toxicity, long half-life circulation, an inherent capability to target specific tissues, and the...
Western blotting, alternatively referred to as immunoblotting, is a method that separates and visualizes proteins using gel electrophoresis, contingent upon the characteristics of the sample or the gel, after the application of particular antibodies. In EV research, this method is commonly utilized to...
Exosomes as Immunotheranostic Nanoparticles Exosomesimmunotherapycancer vaccinetheranosticsnanoparticlesnanomedicineExosomes are small biological membrane vesicles that measure 30 to 100 nm in diameter. They ... G Natasha,B Gundogan,A Tan,... - 《Clinical Therapeutics》 被引量: 100发表: 2014年 Exosomes ...
(PMA) as reported previously [34]. The differentiated cells were infected with DENV 2 virus (moi 2) followed by treatment with GME or CME for 48 h and infectivity of DENV was analyzed by immunoblotting and flow cytometry. We observed that the GME treatment reduced DENV-2 infection evident ...
exosomes as drug carriers can improve drug inhibition and bioavailability and reduce drug side effects [71,72]. This kind of RNA nanoparticles can improve the targeting ability and deliver therapeutic drugs to specific cancer cells. It has been reported that RNA nanoparticles can be used to ...
Theranostic small interfering RNA nanoparticles in cancer precision nanomedicine Wiley Interdisc. Rev. Nanomed. Nanobiotechnol., 12 (2) (2020), Article e1595 View in ScopusGoogle Scholar [31] X. He, G. Kuang, Y. Wu, C. Ou Emerging roles of exosomal miRNAs in diabetes mellitus Clin. Transl...
As a drug delivery system, exosomes outperform other delivery platforms such as lipid nanoparticles, liposomes, and polymeric nanomicelles when it comes to disease-related applications[24]. The major advantages are as follows: (1) high targeting capacity increases drug use efficiency and decreases dru...