Exosomes as immunotheranostic nanoparticles. Clin Ther. 2014;36(6):820–9. Article CAS Google Scholar Simpson RJ, Jensen SS, Lim JW. Proteomic profiling of exosomes: current perspectives. Proteomics. 2008;8(19):4083–99. Article CAS PubMed Google Scholar Yellon DM, Davidson SM. Exosomes:...
In recent years, exosomes have come into focus as “natural nanoparticles” for use as drug delivery vehicles owing to their low cytotoxicity, ability to maximize the bioavailability of drugs, and exquisite target-homing specificity [23,24]. The therapeutic potential of exosomes is reflected by the...
Exosomes as Immunotheranostic Nanoparticles Exosomesimmunotherapycancer vaccinetheranosticsnanoparticlesnanomedicineExosomes are small biological membrane vesicles that measure 30 to 100 nm in diameter. They ... G Natasha,B Gundogan,A Tan,... - 《Clinical Therapeutics》 被引量: 100发表: 2014年 Exosomes ...
Chemical decoration: The properties of the exosome surface bilayer can be modified by cholesterol-binding RNA nanoparticles. These RNA nanoparticles can be used to display chemical ligands (such as folic acid), chemical drugs, or RNA adapters on the exosome surface. body. Folate receptors are abund...
2. Surface-functionalized exosomes as drug delivery systems 4. Design of exosomes and artificial nanovesicles for disease-specific therapeutics 5. Biomaterials engineered exosomes and exosome-like nanovesicles for enhanced retention 6. Conclusion and perspectives Declaration of competing interest Acknowledgments...
Table 1 Theranostic properties of Exos as in patients with BC Full size table Conclusions Malignant BC exhibits high morbidity and mortality in humans. The promotion of blood supplements and the formation of vascular units within the tumor niche can help the cancer cells proliferate and metastasize...
As a drug delivery system, exosomes outperform other delivery platforms such as lipid nanoparticles, liposomes, and polymeric nanomicelles when it comes to disease-related applications[24]. The major advantages are as follows: (1) high targeting capacity increases drug use efficiency and decreases dru...
Western blotting, alternatively referred to as immunoblotting, is a method that separates and visualizes proteins using gel electrophoresis, contingent upon the characteristics of the sample or the gel, after the application of particular antibodies. In EV research, this method is commonly utilized to...
administration, exo- somes derived from MSCs were found to have been trans- ported to the hippocampus, the central region associated with AD.101 Thus, the specific migration and homing abilities of MSC-derived exosomes could pave the way for their use as multifunctional theranostic agents in AD....
Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenot...