the loading methods of therapeutic molecules, the efficiency of cell uptake of exosomes. Exosomes derived from different cell types have diverse functions. For example, human embryonic kidney (HEK293) cells have been widely used in the field of biopharmaceutical manufacturing owing to the advantages o...
exosomes derived from adipose mesenchymal stem cells; AIFM3, apoptosis-inducing factor, mitochondrion-associated 3; AKT, protein kinase B; BMSC-exo, exosomes derived from bone marrow mesenchymal stem cells; CHK2, checkpoint kinase 2; DMBT1, deleted in malignant brain tumors 1; EZH2, enhancer...
Unfortunately, a simple and reliable method to separate exosomes has yet to be developed. As can be expected, the lack of a standardized method for extraction and purification has contributed to suboptimal inter-laboratory correlation and difficulty in comparison studies. Traditional techniques such as...
They are also extensively being used in cancer immunotherapy. On the other hand, exosomes are naturally occurring nanosized extracellular vesicles that serve an important role in cell–cell communication. Importantly, the exosomes also have proven their capability to carry an array of active ...
Exosomes are nanosized extracellular vesicles that influence different facets of cell biology and mediate both short and long-range intercellular communica... Y Ale,N Nainwal - 《Journal of Drug Delivery Science & Technology》 被引量: 0发表: 2024年 加载更多来源期刊 Critical reviews in therapeutic...
Lung cancer (LC) is among the leading causes of death all over the world and it is often diagnosed at advanced or metastatic stages. Exosomes, derived from
Exosomes are a type of extracellular vesicle actively secreted by almost all eukaryotic cells. They are ideal candidates for reliable next-generation biomarkers in the early diagnosis and therapeutic response evaluation of cancer. Thus, the quantification of exosomes is crucial in facilitating clinical re...
Exosomes have a crucial function in the TME and can act as a diagnostic and prognostic marker for the alteration of TME and the progression of cancer to a certain degree [20]. Their importance stems from their ability to enable intercellular communication and convey a diverse range of micro-mo...
(SiO2) have also been used as the core of nanoparticles in SNAs syntheses [34]. However, the use of organic and biocompatible nanoparticle templates without long-term toxicity (i.e. liposomes, proteins, and block copolymer nanostructures) is ideal for in-vivo applications of SNAs [34]. ...
(Fig.6). Exosomes have been shown to inherently target specific cells and evade rapid clearance by the immune system, because of the unique surface molecules [138]. Li et al. developed exosome-mimetic NPs encapsulating rapamycin (RN) and subsequently incorporated these into microspheres (RNM). ...