Cancer vaccines are expected to play a therapeutic function in combination therapy for individuals with advanced or metastatic tumors [144]. Melief et al. found that an effective cancer vaccine design needs to allow for the emergence of vigorous effector CD4 + and CD8 + T-cell response...
189]. Recent studies have shown that CAR-T cell-derived exosomes as a cell-free therapy not only retain most of the functions of CAR-T cells but also have greater therapeutic efficiency, higher controllability, lower toxicity, and
Nucleic acid-based treatments, particularly messenger RNA (mRNA), have played a pivotal role in recent advances in RNA-based vaccination, protein replacement therapy, gene editing, and cancer immunotherapy [2]. Recently, two mRNA vaccines targeting severe acute respiratory coronavirus type 2 (SARS-...
Finally, we validated the potential of EXPLOR-mediated intracellular protein delivery forin vivoapplication. To test the intracellular delivery of Cre recombinase containing EXPLORs (Cre:EXPLORs), we cloned a vector for Cre-conjugated mCherry-CRY2 (Cre-mCherry-CRY2) protein. Unlike mCherry-CRY2 ...
44. Fung ME, Thébaud B. Stem cell-based therapy for neonatal lung disease —it's in the juice. Pediatr Res 2014;75:2–7. 45. Waszak P, Alphonse R, Vadivel A, et al. Preconditioning enhances the paracrine effect of mesenchymal stem cells in preventing oxygen- induced neonatal lung ...
Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy 2019, Acta Biomaterialia Show abstract Sinusoidal communication in liver fibrosis and regeneration 2016, Journal of Hepatology Show abstract Pathogenesis of Nonalcoholic Steatohepatitis 2016, Gastroenterology Show abs...
Stem cell therapy for the repair of damaged myocardium has evolved into a promising treatment for ischemic heart disease. MSC-based therapy, originating from bone marrow, adipose tissue, or umbilical cord cells, continues to gain consent and appeal because of the large body of preclinical evidence...
Advanced hepatocellular carcinoma (HCC) can be treated with sorafenib, which is the primary choice for targeted therapy. Nevertheless, the effectiveness of sorafenib is greatly restricted due to resistance. Research has shown that exosomes and circular RNAs play a vital role in the cancer’s malignan...
addressed before exosome-based therapy for NSCLC may reach its full potential. Despite these obstacles, recent advances in exosome research and technology offer optimism for the development of reliable and efficient treatments that will affect the management of NSCLC and other tumors in the near ...
16. Johnsen et al., “A comprehensive overview of exosomes as drug delivery vehicles-endogenous nanocarriers for targeted cancer therapy,”Biochim. Biophys. Acta1846(1): 75-87 (2014). 17. Kaur et al., “CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by...