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Cancer vaccines are expected to play a therapeutic function in combination therapy for individuals with advanced or metastatic tumors [144]. Melief et al. found that an effective cancer vaccine design needs to allow for the emergence of vigorous effector CD4 + and CD8 + T-cell response...
Herein, our study provides a novel approach for perimenopausal depression therapy using exosome-sheathed nanogel as drug carriers for the efficient delivery of anti-perimenopausal and anti-depressive drugs. Materials and methods Regents and materials All reagents were of analytical quality. AG 50 W-X8 ...
Cancer vaccines are expected to play a therapeutic function in combination therapy for individuals with advanced or metastatic tumors [144]. Melief et al. found that an effective cancer vaccine design needs to allow for the emergence of vigorous effector CD4 + and CD8 + T-cell response...
IL-2 [42], which can then be used for the development of therapeutic vaccines for tumor immunotherapy. In addition, when used as a drug carrier, DEX has been shown to stimulate cytotoxic T cells in cancer therapy and inhibit tumor growth in animal models. Lu et al. [43] treated a ...
collagen depletion mice model. In addition, intradermal delivery of exosome loaded with mRNA using a microneedle array improved and prolonged collagen synthesis and replacement in the animal dermis [111]. Thus, this system has the potential to be a protein replacement therapy for treating photoaged ...
The functional delivery of RNA molecules is an emerging approach to vaccination and therapy (1, 2). Although naked mRNA delivery has been reported (3, 4, 5), its efficacy is limited by high rates of plasma RNA degradation, poor cellular entry, and nucleic-acid-induced inflammatory responses ...
For example, the exosomes lack the specific cell-targeting capability, which highly hampers the delivery efficiency for various disease therapy. In addition, sometimes it is necessary to integrate new drugs into exosomes to provide or enhance the therapeutic effect. To this end, various ...
Once it penetrates the skin, retinol is responsible for strengthening the epidermal layer and inhibit the activity of metalloproteinases which are involved in collagen degradation [92,93]. One of the widely used physical therapy is laser treatment capable of production of collagen and elastin, dermal...
The interaction between CSC-exo and other elements in the TME is pivotal for tumor progression, making their integration into precision therapy a crucial clinical objective. By targeting CSCs and disrupting the communication between CSC-exo and the TME, we could potentially impede tumor progression, ...