Yang T, Fogarty B, LaForge B, Aziz S, Pham T, Lai L, et al. Delivery of small interfering RNA to inhibit vascular endothelial growth factor in zebrafish using natural brain endothelia cell-secreted exosome nanovesicles for the treatment of brain cancer. AAPS J. 2017;19(2):475–86. CASP...
Photodynamic therapy (PDT) is a non/minimally invasive cancer treatment approach, exploiting the photosensitizer (PS)-generated ROS to treat cancers131(Table2). Engineered exosome-based PDT is mainly classified into three categories: (1) the laser irradiation generates ROS, inducing ferroptosis in tum...
Exosome-based immunotherapy: a promising approach for cancer treatment. Mol Cancer. 2020;19:160. Théry C, Boussac M, Véron P, Ricciardi-Castagnoli P, Raposo G, Garin J, et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic ...
As research in this field continues to evolve, the potential of exosomes in the realm of sepsis treatment becomes increasingly evident. This review emphasizes the necessity for further investigation into the multifaceted roles of exosomes, to harness their capabilities for more effective, targeted, and...
As byproducts of programmed cell death, exosomes also function as indicators of disease progression, assisting in diagnosis and evaluating treatment response by identifying unique molecular markers. Nevertheless, further research is needed to comprehensively comprehend the roles of exosomal biomarkers and the...
Exosomes derived from AFs induced by high phosphorus promote VSMCs calcification.AWestern blot was used to determine the effect of AFsNPi-Exos or AFsHPi-Exos treatment on Runx2 and BMP2 protein levels in 3.5 mM Pi-induced VSMCs. VSMCs treated with 0.9 mM Pi plus PBS were used as contr...
4A). To confirm the results obtained by the viability assay, we also measured caspase 3 and caspase 1 activities in response to EXi-RVFV treatment. For these studies, U937 cells were pretreated with either EXi-RVFV, or EXu as control, and incubated for 48 h before analysis. Confirming the...
Thus, in this manner, proteomic profiles of exosomes could be used to improve prognosis predictions, and diagnostic accuracy but also to predict of potential disease relapse in patients receiving chemotherapy or radiation treatment. Interestingly, in chronic myeloid leukemia (CML), Mineo et al.90 ...
Exosome transplantation is an efficient treatment option for CVD, as several basic and clinical studies have confirmed decreased immune rejection and improved survival, as compared with cell transplantation. miRNAs and proteins released from various cardiac cell exosomes regulate target gene expression and ...
Mead and Tomarev, “Mesenchymal stem cell-derived exosomes for the treatment of traumatic and degenerative eye disease,” ARVO, Baltimore (Abstract) (May 2017). Mead and Tomarev, “Retinal ganglion cell neuroprotection by growth factors and exosomes: lessons from mesenchymal stem cells,” Neural...