Bmc Molecular BiologyAmit M, Sela N, Keren H, Melamed Z, Muler I, Shomron N, et al.: Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene. BMC Mol Biol 2007, 8(109):109.Amit M, Sela N, Keren H, Melamed Z, Muler I, et al. Biased ...
1a), suggesting a role in the flower and possibly other processes. Moreover, the similar expression levels in leaves between GRP20 and a constitutively expressed gene EF1α (Supplementary Fig. 1a) suggest that the level of GRP20 expression in leaves is not very low, just much lower than ...
(Fig. 1b). The mRNA generated byexon skippingis expressed at a very low level and only can be detected by RT-PCR, suggesting that exon skipping is not the main mechanism of circular RNA biogenesis (Conn et al., 2017). However, exon skipping provides a mechanism for generating circular...
We also aimed to identify factors associated with alternative exon use in neuroblastoma and sought to gain novel biological insights into neuroblastoma biology by exon- level gene expression analyses. MATERIALS AND METHODS Patient cohort The 113 primary neuroblastoma specimens were from tumour banks in ...
https://ror.org/03a2tac74grid.418025.a0000 0004 0606 5526The Molecular Psychiatry LaboratoryThe Florey Institute of Neuroscience and Mental Health Parkville VIC AustraliaFabian J. Theishttps://ror.org/00cfam450grid.4567.00000 0004 0483 2525Institute of Computational BiologyHelmholtz Center Munich ...
We interrogated the CALVADOS residue-level model22,23(Extended Data Fig.3a,b) to determine the effect of increasing the degree of protonation (qHis) on the intermolecular contacts within simulated condensates. The ratio between the contacts from simulations corresponding toqHis = 0.50 compared ...
In three lines, the transgene is ubiquitously expressed at both mRNA and protein level. Transgenic mice exhibit a progressive neurological phenotype that exhibits many of the features of HD, including choreiform-like movements, involuntary stereotypic movements, tremor, and epileptic seizures, as well ...
SaurabhBansal,BishwajitKundu, inAdvances in Protein Molecular and Structural Biology Methods, 2022 3.2.2.1Exon shuffling In vitroexon shufflingmethod was first described by Kolkman and Stemmer53. This method creates new genes by combining two or more exons from different genes or by duplicating the ...
We interrogated the CALVADOS residue-level model22,23(Extended Data Fig.3a,b) to determine the effect of increasing the degree of protonation (qHis) on the intermolecular contacts within simulated condensates. The ratio between the contacts from simulations corresponding toqHis = 0.50 compared ...
We investigated the biology underlying the candidates detected from our screens. To verify that our assays robustly captured known regulators of AS, we performed Gene Ontology (GO) analysis on the full list of final hits. When compared with a background of the complete tethering library, GO anal...