For example, anti-GD2 CAR was modified by shortening the VH sequence and changing the hinge and transmembrane domain of human CD8α instead of the Ig-derived hinge and CD28 transmembrane domain, resulting in reduced self-dimerization as well as lower expression of an exhaustion marker PD-1 [40...
Programmed cell death marker-1(PD-1) expression, a critical checkpoint for T cell exhaustion, can be modulated by interleukin-10, which also mediates apoptotic T cell cytopenia. We aimed to measure the level of PD-1 expression and to investigate its correlation with IL...
exhaustion marker 衰竭性表面标志物 Tc9 Cells Are Less Exhausted and Developed into Full Effector ...
Treatment resulted a significant decrease of CD4+Tim-3+T-cells frequencies from 7.5% (0.2–32.3%) to 6.4% (0.7–24.8%), P = 0.0398 and CD4+PD-1+Tim-3+T-cells from 1.9% (0.3–9.4%) to 1.3% (0.0–7.6%), P < 0.0001; (Fig.1). The frequency of CD4+cells expressing P...
Programmed cell death marker-1(PD-1) expression, a critical checkpoint for T cell exhaustion, can be modulated by interleukin-10, which also mediates apoptotic T cell cytopenia. We aimed to measure the level of PD-1 expression and to investigate its correlation with IL-10 serum levels in ...
among SARS-CoV-2-specific MHC-I multimer+cells are not exhausted but functionally active in the acute and early convalescent phases of COVID-19 and that PD-1 needs to be considered an activation marker rather than an exhaustion marker in patients with COVID-19. In addition, there was no ...
PD-1 has been identified as a marker of exhausted T cells in chronic disease states, and blockade of PD-1–PD-1L interactions has been shown to partially restore T cell function. We have found that T cell immunoglobulin mucin (Tim) 3 is expressed on CD8+ tumor-infiltrating lymphocytes (...
Since PD-1 and LAG-3 were highly expressed by CD4+ T cells relative to the expression levels in the HC group, we analyzed the association between the PD-1 and LAG-3 expression levels on CD4+ T cells and the serum ALT levels (as a marker of hepatic injury) together with the HBV DNA...
which in turn drove the exhaustion of T cells. CD4+and CD8+T cells were significantly decreased in COVID-19 patients, the number of T cells was negatively correlated with serum IL-6, IL-10 and TNF-α concentrations. The level of PD-1, a marker of T cell exhaustion, was significantly ...
10 The expression of ETV7 is correlated with the expression of memory genes and exhaustion marker genes and generation of anti-MSLN CAR T-shETV7 therapeutic system. a-c, Related to Fig. 7f and g. Mouse naive CD8+ T cells were stimulated with anti-mouse CD3/CD28 antibodies for 24 ...