For example, anti-GD2 CAR was modified by shortening the VH sequence and changing the hinge and transmembrane domain of human CD8α instead of the Ig-derived hinge and CD28 transmembrane domain, resulting in reduced self-dimerization as well as lower expression of an exhaustion marker PD-1 [40...
Anti-PD-L1 treatment reduces exhaustion marker expression on tumour-specific CD8+ T cells.Stephen J. P. BlakeAlan L. H. ChingTony J. KennaRyan GaleaJustin LargeHideo YagitaRaymond J. Steptoe
During chronic hepatitis C virus (HCV) infection, both CD4+and CD8+T-cells become functionally exhausted, which is reflected by increased expression of programmed cell death-1 (PD-1) and T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3), and elevated anti-inflammatory interleuk...
衰竭性CD8+T细胞。这群细胞表面持续性高表达PD-1抑制性受体,除了PD1以外,抗原特异性的CD8+T细胞表面还...
Programmed cell death marker-1(PD-1) expression, a critical checkpoint for T cell exhaustion, can be modulated by interleukin-10, which also mediates apoptotic T cell cytopenia. We aimed to measure the level of PD-1 expression and to investigate its correlation with IL-10 serum levels in ...
10 The expression of ETV7 is correlated with the expression of memory genes and exhaustion marker genes and generation of anti-MSLN CAR T-shETV7 therapeutic system. a-c, Related to Fig. 7f and g. Mouse naive CD8+ T cells were stimulated with anti-mouse CD3/CD28 antibodies for 24 ...
PD-1 has been identified as a marker of exhausted T cells in chronic disease states, and blockade of PD-1–PD-1L interactions has been shown to partially restore T cell function. We have found that T cell immunoglobulin mucin (Tim) 3 is expressed on CD8+ tumor-infiltrating lymphocytes (...
Since PD-1 and LAG-3 were highly expressed by CD4+ T cells relative to the expression levels in the HC group, we analyzed the association between the PD-1 and LAG-3 expression levels on CD4+ T cells and the serum ALT levels (as a marker of hepatic injury) together with the HBV DNA...
which in turn drove the exhaustion of T cells. CD4+and CD8+T cells were significantly decreased in COVID-19 patients, the number of T cells was negatively correlated with serum IL-6, IL-10 and TNF-α concentrations. The level of PD-1, a marker of T cell exhaustion, was significantly ...
among SARS-CoV-2-specific MHC-I multimer+cells are not exhausted but functionally active in the acute and early convalescent phases of COVID-19 and that PD-1 needs to be considered an activation marker rather than an exhaustion marker in patients with COVID-19. In addition, there was no ...