The intracellular signalling pathways that mediate the effects of growth factors and oncogenes on cell growth and transformation offer new targets for developing drugs for the treatment of cancer. This is a novel approach that presents new types of challenges to anticancer drug development. We have ...
Nanotechnology has greatly impacted the world of medicine. For instance, nanowires can be used in the detection of diseases including cancer. In addition, nanoshells and nanococoons can be used to deliver anticancer drugs to specific tumor cells. ...
Carvalho IF, Silva MM, Moreira JN, Simoes S, Sa e Melo ML (2010) Sterols as anticancer agents: synthesis of ring B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis. J Med Chem 53(21):7632–7638. doi:10.1021/jm100769e Chiang YR, Ismail W, Muller M, Fuchs G (2007...
Nucleoside analogs are produced artificially for use as therapeutic drugs. They have antiviral properties and therefore are used to prevent further growth of pathogenic viruses inside the host cell. They may also be used as anticancer agents. ...
Summary This study aimed to evaluate the possible anticancer effects of two different pillar[5]arene derivatives (5Q-[P5] and 10Q-P[5]) on two different pa... K Mehmet Ali,K Serkan,D Tugce,... - 《Investigational New Drugs》 被引量: 0发表: 2023年 ...
immune system is important to fully grasp the effect of EOs as immunomodulators and how they augment, modify and influence the immune response, either as immunosuppressors (in allergies, as anticancer agents, etc.) or as immunopotentors (in the cases of immunodeficiencies to prevent infections ...
The nab-based formulation platform is a characteristic example of how the distribution and targeting of an anticancer drug can be tailored and thus its efficacy and safety be improved. Another example of using formulation to improve efficacy comes from the oral delivery of peptides. Semaglutide is...
ramifenazone, lonazolac, and rimonabant, drugs approved as COX-2 inhibitors [13,14,15,16], crizotinib [17] and paropanib [17] as anticancer drugs, sildenafil [17] (Viagra) PDE5 inhibitor, zometapine [18] as antidepressant, ocinaplon [19] as anxiolytic (Figure 1), and many others....
The termpersonalized medicineis sometimes considered to be synonymous withtargeted therapy, a form of treatment centred on the use of drugs that target specific molecules involved in regulating the growth and spread ofcancer. Among the first successful targeted therapies was the anticancer drugimatinib,...
Role of lipid rafts/caveolae in the anticancer effect of endocannabinoids Mini Rev Med Chem, 12 (2012), pp. 1119-1126 Google Scholar [87] N. Rimmerman, H.B. Bradshaw, E. Kozela, R. Levy, A. Juknat, et al. Compartmentalization of endocannabinoids into lipid rafts in a microglial cell...