The most important example of this in recent terrestrial history is the conversion of buried vegetable residues to coal. We have synthesized hairpin templates bearing propynyl pyrimidine residues to examine their effect on template-directed non-enzymatic oligomerization. Of the 7 amino acid substitutio...
a. Pyrimidine dimer b. Transition c. Tautomerization d. Transversion DNA mutation: DNA mutation or alteration in the nucleotide sequence of a DNA molecule can occur during DNA replication or recombination process in the cell cycle. Three kin...
in which - C represents an optionally modified purine or pyrimidine base, - the bond A-B represents a double bond, R2 a hydrogen atom, and R1 a CH2-Nu radical, or - the bond A-B represents a saturated hydrocarbon bond, R2 a nucleophilic radical Nu, and R1 the methylidene radical, wi...
Base catalyzed cyclization of ethyl 4-[2-(2-amino-4,5-dimethoxyphenyl)ethyl]-2-phenylpyrimidine-5-carboxylate, derived from ethyl 4-methyl-2-phenyl-5-pyrimidinecarboxylate and 3,4-dimethoxy-6-nitrobenz-aldehyde, gave 5,6-dihydro-8,9-dimethoxy-3-phenylbenzo[b]pyrimido[4,5- f ]azocine-12(...
They are responsible for fixing cyclobutane pyrimidine dimers (CPDs) created in DNA by UV light. They have been divided into two classes on the basis of amino acid sequence divergence early in the evolution process (van Oers et al., 2008). Class II photolyases are 450–550 amino acids ...
This is also true for compounds modulating pyrimidine biosynthesis, such DHODH (Hoffmann et al., 2011). Statins are another example; they showed strong anti-HCV activity in vitro (Ikeda et al., 2006), but gave largely disappointing results in clinical studies (Bader et al., 2008, Sezaki et...
The role of DNA polymerase beta in single nucleotide base excision repair (BER) was known, but there was incomplete understanding of the function of this enzyme in long patch base excision repair (LP BER). In the study model, an apurinic or apyrimidine (AP) site from unprompted loss of ...
The higher level of glycine at the stationary phase could be associated with a partial or complete reduction in the biosynthesis of purine/pyrimidine and/or cell wall components, as glycine serves as an essential precursor in both pathways. There is a remarkable ability in bacterial cells to ...
The vibrational modes of the Cytidine-water at 7.3 THz and the Cytidine at 7.1 THz both originated from the weak out-of-plane distortion of ribose and out-of-plane swing of NH2 attached to the pyrimidine ring. The vibrational modes of the Cytidine-water at 8.6 THz came from the out-of-...
The case of ultraviolet light is presented and includes the following: (a) Description of the distribution of cyclobutane pyrimidine dimers within defined DNA sequences. Considerations of the effect of neighboring base composition, dose rate, and double- or single-stranded property of the DNA are ...