The compounds that follow the rule of aromaticity by Huckel are said to be aromatic. Such a system is cyclic, planar, conjugated, and will contain... Learn more about this topic: Pyrimidine | Definition, Bases & Structure from Chapter 5/ Lesson 10 ...
Trimethoprim is derived from pyrimidine and belongs to a group of compounds well characterized for their antibacterial activity. Trimethoprim inhibits the enzyme dihydrofolate reductase, and has been shown to act as a sulfonamide potentiator [7]. In 1971, a combination of trimethoprim and ...