Further, we identified accumulation of IL17A+Foxp3+ and ex-Th17 Foxp3+ cells in tumor bearing mice, indicating progressive direct Th17-into-Treg cell conversion as a novel phenomenon in cancer.Moreover, we determined the importance of the Th17 cell plasticity for tumor induction and/or ...
Th17 cells are a novel source of Foxp3+cells by converting into ex-Th17 Foxp3+cells, and this helps to reconcile the contradictory information about the relevance in particularly of Th17 subset in immune surveillance.
如图4d,exFoxp3 TH17细胞与BMMs共同培养,发现在没有滑膜成纤维细胞存在的时候,exFoxp3 TH17细胞也有将BMMs诱导生成破骨细胞的能力。为了探究RANKL对exFoxp3 TH17细胞和滑膜成纤维细胞的影响,文中在共同培养系统中使用exFoxp3 TH17细胞(从Lck-cre(T淋巴细胞特异cre小鼠) Tnfsf11(编码RANKL)flox/△ Foxp3hCD2 小鼠...
Th17 cells can switch to become ex-Th17 cells that no longer produce IL-17 but produce IFN-γ. These ex-Th17 cells are also called nonclassical Th1 cells because of their ability to produce IFN-γ, similar to Th1 cells; however, it is unclear whether they resemble Th1 or Th17 cells in...
Here we show that Th17 cells are a source of tumour-induced Foxp3 þ cells. In addition to natural (n)Treg and induced (i)Treg cells that develop from naive precursors, suppressive IL-17A þ Foxp3 þ and ex-Th17 Foxp3 þ cells are converted from IL-17A þ Foxp3neg cells in...
01 来自多个组织的Th17和ex-Th17细胞的细胞图谱 为了表征组织内和组织间Th17细胞的多样性,本研究构建了Il17aCreGFP X Rosa26tdTomato 小鼠,从该小鼠脾脏(SPL)、派氏淋巴结(PP)、肠系膜淋巴结(MLN)、小肠(SI)和结肠(COL)中获取Th17和ex-Th17细胞(Th17前体)进行单细胞转录组测序和TCR测序,发现肠组织中的tdTamato...
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Th17 in sensitized human lymphocytes ex vivo ?HumansInterleukin-4Signal TransductionInterleukin-23LymphocytesAntigens, CD3Interleukin-17STAT3 Transcription FactorInstitut für Umwelt und Gesundheit (IUG) and University of Applied Sciences HS Fulda, FB:Oe, Biochemistry Lab, Marquardstr. 35, D-361039, ...
Ex vivo PBMC cytokine profile in familial Mediterranean fever patients: Involvement of IL-1beta, IL-1alpha and Th17-associated cytokines and decrease of Th1 and Th2 cytokines. Cytokine. 2014; 69 :248–54.Ibrahim JN, Jounblat R, Delwail A, Abou-Ghoch J, Salem N, Chouery E, Megarbane...
Moreover, expression of another critical Th17-cell-related transcription factor, signal transducer and activator of transcription 3, was reduced by FO. Dietary FO reduced the surface expression of both IL-6R and IL-23R on polarized Th17 cells (P ≤ 0.05), thus interfering with the promotive ...