ANTIBIOTIC-RESISTANCEMOLECULAR-MECHANISMSSPATIAL STRUCTUREBIOFILM FORMATIONCHEMICAL WARFARESTRESS RESPONSESMEMBRANE STRESSThroughout their evolutionary history, bacteria have faced diverse threats from other microorganisms, including competing bacteria, bacteriophages and predators. In response to these threats, they ...
antibiotic resistanceevolutionMfdmutagenesisRpoSSOS responsestress responsetranscription‐associated mutagenesisDrug resistant bacterial infections have led to a global health crisis. Although much effort is placed on the development of new antibiotics or variants that are less subject to existing resistance ...
Directed evolution can be a powerful tool to predict antibiotic resistance. Resistance involves the accumulation of mutations beneficial to the pathogen while maintaining residue interactions and core packing that are critical for preserving function. The constraint of maintaining stability, while increasing ...
Hall BG. Anti-infectives: predicting the evolution of anti- biotic resistance genes. Nat Rev Microbiol 2004; 2: 430-435.Hall, B.G. (2004) Predicting the evolution of antibiotic resis- tance genes. Nat Rev Microbiol 2: 430-435.Hall B G.Predicting the evolution of antibiotic resistance ...
The evolution of antibiotic resistance is becoming not only a clinical problem for the therapy of infectious diseases, and hence for the progress of medicine, the effect of antibiotics on the microbiosphere might also result in unexpected global ecological effects, producing changes in the structure ...
“Antibiotic resistance is one of our main problems in medicine,” Santos-Lopez said. “We have to develop new treatments, and one idea is to take advantage of what the field calls ‘collateral sensitivity.’ When bacteria evolve resistance to one drug, it can expose a vulnerability to a di...
The evolution of bacterial pathogens towards antibiotic resistance is not just a relevant problem for human health, but a fascinating example of evolution that can be studied in real time as well. Although most antibiotics are natural compounds produced by environmental microbiota, exposure of bacterial...
Gene-drug interactions and the evolution of antibiotic resistance. The evolution of antibiotic resistance is shaped by interactions between genes, the chemical environment, and an antibiotic's mechanism of action. This thesis explores these interactions with experiments, theory, and analysis, seeking a ...
Antibiotic resistance genes as new pollutant have been received increasingly wide attention, and their mechanisms of access and routes of transmission have become the focus of research. tet(M) gene is a common tetracycline resistance gene in many environmental media. In this study, the genetic ...
Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the identification of collateral sensitivities, wherein evolution under a first drug induces susceptibility to a second. Here, we report that sequential ...