ANTIBIOTIC-RESISTANCEMOLECULAR-MECHANISMSSPATIAL STRUCTUREBIOFILM FORMATIONCHEMICAL WARFARESTRESS RESPONSESMEMBRANE STRESSThroughout their evolutionary history, bacteria have faced diverse threats from other microorganisms, including competing bacteria, bacteriophages and predators. In response to these threats, they ...
antibiotic resistanceevolutionMfdmutagenesisRpoSSOS responsestress responsetranscription‐associated mutagenesisDrug resistant bacterial infections have led to a global health crisis. Although much effort is placed on the development of new antibiotics or variants that are less subject to existing resistance ...
作者: Fernando Baquero and Jesú,zquez 摘要: World-wide spread of bacterial resistance to antimicrobial agents may limit the future progress of medicine. A huge environmental antibiotic pressure, resulting from industrial production and marketing of these drugs, has simultaneously contributed to the ...
The evolution of antibiotic resistance is one of the most serious challenges facing modern healthcare [1], causing over 1.2 million deaths and tens of millions of extra days in recovery per year [2,3]. While the evolution of antibiotic resistance has been extensively studied in laboratory monoc...
The evolution of bacterial pathogens towards antibiotic resistance is not just a relevant problem for human health, but a fascinating example of evolution that can be studied in real time as well. Although most antibiotics are natural compounds produced by environmental microbiota, exposure of ...
Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homologous ...
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities, and the environment concomitant with their use. The extraordinary genetic capacities of microbes have benefitted from man's overuse of antibiotics to exploit every source of resistance genes and every...
Infections, especially peritoneal dialysis-related peritonitis, are unavoidable because of lapses in technique and the slow worsening of systemic and peritoneal defense associated with aging and dialysis. The selective pressure inherent in the use of antibiotics shapes the pattern of antibiotic resistance ...
“Antibiotic resistance is one of our main problems in medicine,” Santos-Lopez said. “We have to develop new treatments, and one idea is to take advantage of what the field calls ‘collateral sensitivity.’ When bacteria evolve resistance to one drug, it can expose a vulnerability to a di...
Antibiotic resistance has become a major public health concern as bacteria evolve to evade drugs, leading to recurring infections and a decrease in antibio... AM Langevin,IE Meouche,MJ Dunlop - 《Msphere》 被引量: 0发表: 2020年 Bacterial persistence promotes the evolution of antibiotic resistanc...