Sign in to download full-size image Fig. 1.The human Ets protein family is subdivided into subfamilies based on the homology within the ETS domain[93, 95, 117, 126–128, 131–147]. The ETS domain and the N-terminal conserved region (NCR), also known as Pointed- or HLH-domain, are...
The Ets1 protein is produced by a variety of tissues. In most cases, its truncated form, ΔVII-Ets1, is expressed along with full-length Ets1. However, ΔVII-Ets1 is barely detectable in astrocytes, astrocytoma and invasive mammary carcinoma cells [91,97]. The lymphoid and haematopoietic ...
Initially the effect of the dominant repressive Elk-Engrailed (Elk-EN) fusion protein in PC12 cells was tested. This fusion contains full-length Elk-1 and the potent transcriptional repression domain from the engrailed transcription factor [8]. Since Elk-EN can bind to the ets motifs on DNA ...
Both inhibitory domains surrounding the DNA-binding domain are conserved, suggesting that Ets-1 p27, like the full-length Ets-1 p51 isoform, is autoinhibited for DNA binding. We showed that Ets-1 p27 binds DNA in the same way as Ets-1 p51 does and that it acts both at a ...
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We have previously shown that the human ETS1 protein (p51-ETS1), when ectopically expressed in colon cancer cell lines, is able to reduce its tumorigenicity without affecting its growth properties. To understand the mechanism of tumor reduction, we have
The addition of two 3-h periods of very dim light, one before and one after a normal 8-h photoperiod, advances sexual maturity in pullets by about a week. This trial tested the hypothesis that dim light given before a short day of normal intensity is linked to form a more stimulatory ...
Interestingly, fragments of c-Ets-1p68 with strong DNA binding activity could be produced by limited proteolysis, indicating that the DNA binding domain is repressed within the full-length molecule. By deletion mapping the DNA binding domain was localized to the most highly conserved region of the...
In these cells, the full suite of differentiation functions is executed only at time of skeletal matrix deposition, hours after ingression at 24 h. Note that expression of differentiation genes long in advance of the actual utilization of their translated products is a characteristic feature of ...
Download: Download full-size image Figure 1. Ets21c Functions Downstream of JNK Signaling in the Intestine (A) Setup and timeline of the TARGET expression system specific for the ISCs/EBs (esgTS) and ECs (Myo1ATS) of adult midguts. (B) qRT-PCR shows ets21c expression in 6-day-old midg...