The primary mechanism of action of ethosuximide against absence seizures is reduction of low-threshold T-type calcium currents in thalamic neurons, although actions at cortical level may also be important. Concomitant therapy with enzyme-inducing antiepileptic drugs (AEDs) such as carbamazepine, ...
It is a drug for treating absence seizures under the trade names Emeside and Zarontin due to the mechanism of action which is ethosuximide is a T-type calcium channel blocker with an IC50 of 12 ± 2 mmol/L. Emeside capsules were discontinued by their manufacturer, Laboratories for ...
Conclusions:We have revealed a conserved neuroprotective mechanism of action of ethosuximide from worms to mammalian neurons. Future experiments in mouse neurodegeneration models will be important to confirm the repurposing potential of this well-established anti-epileptic drug for treatment of human ...
Ethosuximide is the drug of choice for treating generalized absence seizures, but its mechanism of action is still a matter of debate. It has long been thought to act by disrupting a thalamic focus via blockade of T-type channels and, thus, generation of spike–wave activity in thalamocortic...
Conclusions:We have revealed a conserved neuroprotective mechanism of action of ethosuximide from worms to mammalian neurons. Future experiments in mouse neurodegeneration models will be important to confirm the repurposing potential of this well-established anti-epileptic drug for treatment of human ...
It is a drug for treating absence seizures under the trade names Emeside and Zarontin due to the mechanism of action which is ethosuximide is a T-type calcium channel blocker with an IC50 of 12 ± 2 mmol/L. Emeside capsules were discontinued by their manufacturer, Laboratories for ...
against absence epilepsy is its ability to reduce the low-threshold calcium current (LTCC) or T (transient) current. These currents underlie the 3-Hz spike wave discharges that are characteristic of absence epilepsy. A blockade of T-calcium current is likely also to be a mechanism used by val...
These results speak against the adequacy of minimal metrazol seizures as a model of human absences. In addition, different development of ESI action against two types of experimental seizures suggests a possibility that there is more than one mechanism of action of ESI....
The primary mechanism of action of ethosuximide against absence seizures is reduction of low-threshold T-type calcium currents in thalamic neurons, although actions at cortical level may also be important. Concomitant therapy with enzyme-inducing antiepileptic drugs (AEDs) such as carbamazepine, ...
Ethosuximide is the drug of choice for treating generalized absence seizures, but its mechanism of action is still a matter of debate. It has long been thought to act by disrupting a thalamic focus via blockade of T-type channels and, thus, generation of spike鈥搘ave activity in ...