Ethionamide is used as an anti-tuberculosis antibiotic and an inducer of hypothyroidism. Mechanism of action Evidence has been presented suggesting that the mechanism of action of ethionamide is similar to that of INH. Similar to INH, ethionamide is considered to be a pro-drug, which is converted...
Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. ETH mechanism of action is thought to be identical to INH although the pathway of activation is distinct from that of INH. ETH...
Acetamide is a second-line drug for the treatment of tuberculosis and is used only in combination with other drugs and for drug-resistant tuberculosis. Acetamide has been associated with transient, as.. What is the Mechanism of Action and Bioavailability of Ethionamide?Title: What is the ...
Johnsson K, King DS, Schultz PG (1995) Studies on the mechanism of action of isoniazid and ethionamide in the chemotherapy of tuberculosis. J. Am. ... K Johnsson,DS King,PG Schultz - 《Journal of the American Chemical Society》 被引量: 426发表: 1995年 加载更多来源...
In this work, the molecular spectroscopic technique was used in a nonconventional way to predict the drug mechanism action of the drug compound, Ethionamide. The formatted molecular charge levels, due to the injection of substitutions in suitable positions, were measured. The molecular geometry ...
However, the ethionamide-TRα interaction is stronger than ethionamide-TRβ interaction. Our study reports a novel mechanism of action of ethionamide-induced hypothyroidism.doi:10.5530/pj.2021.13.150Lesmana, RonnyShidqi, Firyali RahmaniGoenawan, Hanna...
Johnsson K, King DS, Schultz PG (1995) Studies on the mechanism of action of isoniazid and ethionamide in the chemotherapy of tuberculosis. J. Am. ... K Johnsson,DS King,PG Schultz - 《Journal of the American Chemical Society》 被引量: 426发表: 1995年 ...
ETH (green), NADP (cyan), FADH2 (blue), and residues (gray) involved in complex stabilization and catalytic mechanism are shown in stick representation. The distance (Å) between ETH, NADP and EthA residues are represented by yellow dashes. 2.4. Free Energy Changes for Y50C and T453I...