While optic neuritis due to ethambutol has been described, the occurrence of this complication is ascribed to the use of the drug in concentrations greater than 15 mg/kg body weight for a duration longer than 3 months. Physicians believe that when used in doses of 15 mg/kg body weight or...
Characterizing ethambutol-induced optic neuropathy with a 3D computer-automated threshold Amsler grid test Ethambutol is commonly used in treatment against tuberculosis and Mycobackrium avium complex infections. Optic nerve toxicity is among the more serious adv... JK Kim,MD Ali Fahimi,W Fink,... ...
optic neuropathyvisual function testContext: Tuberculosis in developed countries is on the rise, and the main treatment ethambutol is known to induce ocular toxicity. However, to date, there are unknown tests or protocols for detecting subclinical ethambutol-induced ocular toxicity, which is important ...
The article concludes that ethambutol can cause not only optic nerve toxicity but also cone dysfunction, and physicians should be aware of these ocular toxicities when prescribing the medication.Konana, Vinaya K.Mooss, VidyaBabu, KalpanaIndian Journal of Ophthalmology...
We find this supportive of our hypothesis that most cases of ethambutol optic toxicity occur in patients who experience either a prolonged course or a high serum level of ethambutol." Key words adverse reactions - Elderly - drug-induced - Ethambutol - Optic-nerve-disorders...
Ethambutol was a possible etiologic agent in optic nerve neuritis.doi:10.1016/0002-9394(74)90684-9Barron, G.J.Tepper, LeoIovine, GinoElsevier Inc.American Journal of OphthalmologyBarron G.J., Tepper L., Iovine G. : Ocular toxicity from ethambutol . Am. J. Ophthalmol, 77:256–260, 1974....
Hence, we conclude that the extended use of ethambutol beyond 2 months results in significant optic nerve toxicity. Further randomized controlled trials with different populations are needed to understand the magnitude of this issue.doi:10.4103/ijo.IJO_1920_22Swapnali Sabhapandit...
Conclusion: Ethambutol toxicity affects not only the optic nerve but probably other retinal elements based upon abnormal mfERG findings.doi:10.1080/08820530600987454Randy H KardonMary C MorriseyAndrew G LeeTaylor & FrancisSeminars in Ophthalmology
The papillomacular bundle seems to be especially involved in ethambutol eye toxicity.doi:10.1016/0168-5597(88)90073-1J.E. PetreraH.C. FledeliusW TrojaborgElsevier Ireland Ltd.Electroencephalography & Clinical NeurophysiologyPetrera JE, Fledelius HC, Trojaborg W (1998) Serial pattern evoked ...
Zoumalan CI, Sadun AA (2007) Optical coherence tomography can monitor reversible nerve-fibre layer changes in a patient with ethambutol-induced optic neuropathy. Br J Ophthalmol 91:839–840 CentralZoumalan CI,Sadun AA.Optical coherence tomography can monitor reversible nerve-fibre layer changes in...