Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for function and pathway analysis. STRING and Cytoscape were used to construct the interaction network, and the MCODE plug-in performed the module analysis. GEPIA, TCGA, and LOGpc databases w...
aThe hepatic steatosis canonical pathway with the significantly regulated genes for liver tissue from mice flown to space compared to ground control mice. The lower panel is the mitochondrial complexes and the significantly regulated genes involved visualized by ShinyGo v0.76.3 and KEGG pathway diagrams...
Biological pro- cesses, molecular functions and KEGG pathways were investigated focusing on enriched terms with a Benjamini adjusted p-value less than 0.05. A Protein-Protein Interaction Network of the differentially expressed genes has been created using STRING63. Flow cytometry analysis. To ...
(B) KEGG pathway analysis shows enrichment of EMT-related pathways in E1- versus E2-supplemented tumors, p < 0.05. (C) Estrogen-starved MCF7 (cFBS) cells were treated with10 nM E1 or E2 for 8 h followed by RNA-seq on 3 biologic repeat samples. Gene Ontology (GO) analysis shows gene...
KEGG ID hsa:2099 IUPHAR/Guide To Pharmacology ID 620 NCBI Gene ID 2099 General References Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature. 1986 Mar 13-19;320(6058):134-9. [...
Gene Ontology functional and KEGG pathway enrichment analysis of differentially expressed genes (DEGs) showed that the extracellular matrix (ECM), extracellular region, ECM-interaction receptor, focal adhesion, cell cycle, apoptosis, and bone-related signaling pathways were disrupted. In these signaling ...
To fully understand the impact on regions that gained or lost methylation in the placenta, KEGG enrichment analysis was performed. Interestingly, gene changes in DNA methylation were mainly involved in estrogen signaling, metabolism, mTOR, and other pathways that are important for placental function (...
analysis were found to be annotated as cancer pathways in KEGG (glioma (hsa05214), non-small cell lung cancer (hsa05223), pancreatic cancer (hsa05212), and prostate cancer (hsa05215) (Table 3)), hence confirming the validity of the choice of this subset of regulatory SNPs in pathway ...
(a) Heatmap representation of the mRNA expression profiling showing selected deregulated genes (**Po0.01) within the TGF-b signaling pathway (annotated with KEGG pathway analysis). (b, c) TGFBR2 mRNA expression levels in MDA-MB-231 or MCF10A cells 2 days after transfection with mimics (**...
Understanding the mechanism of the sexual dimorphism in susceptibility to obesity and metabolic syndrome (MS) is important for the development of effective interventions for MS. Here we show that gut microbiome mediates the preventive effect of estrogen