Similarly, we examined ER signaling activity in these four female cancer samples using the HALLMARK_ESTROGEN_RESPONSE_LATE gene set via GSVA to generate late estrogen response enrichment scores for samples of the four cancer types to classify these samples either high or low enrichment scores, but ...
Responsible for female sexual characteristics, estrogen stimulates and triggers a response from at least 300 tissues, and may help some types of breast cancer to grow. After menopause, the production of the hormone gradually stops. Mentioned in: Anabolic Steroid Use, Bone Disorder Drugs, ...
We found evidence of a causal relationship between these hormones and breast cancer, based on the following criteria: consistency, dose-response pattern, biologic plausibility, temporality, strength of association, and coherence. The magnitude of the increase in breast cancer risk per year of hormone...
Higher expression of estrogen response genes in the primary tumor is associated with a greater risk for late recurrence in patients with ER1/HER2-breast cancerBackground: Antibody-drug conjugates (ADCs), consisting of an antibody designed against a specific target at the cell membrane linked with ...
Ductal sidebranching was observed in early postmenopausal mice, whereas duct end enlargement was observed in late postmenopausal mice. The differences in morphological response to E+R5020 in 5 week post OVX were associated with an inability of E to induce progesterone receptors (PR) in the late ...
The ER dimer binds to estrogen response elements located in the promoter region of target genes. The ER-DNA complex recruits a cascade of coactivators and other proteins to the promoter region to form a transcription apparatus. In contrast, interactions of ERs with antagonists also promote ...
Simultaneously, estradiol (E2) stimulates a robust and biphasic activation of ERK2 and transcription of the late response-gene Fra1 associated with epithelial-to-mesenchymal transition [2]. Research has demonstrated that the removal of estrogen not only suppresses the production of the abovementioned ...
Define Anti-estrogen. Anti-estrogen synonyms, Anti-estrogen pronunciation, Anti-estrogen translation, English dictionary definition of Anti-estrogen. n. Abbr. AI Any of several drugs that affect the levels of steroids in the blood by inhibiting the enzym
The molecular mechanisms involved in the estrogen regulation of several cytokine/late gene promoters produced by bone cells have been elucidated. Many of these promoters lack consensus estrogen response elements (EREs) and thus have revealed alternative mechanisms of transcriptional control by the ER. In...
Determination of breast cancer estrogen receptor (ER) status as a predictor of tumor response to adjuvant endocrine therapy remains a mainstay of breast ca... G E,Nichols,H F,... - 《American Journal of Clinical Pathology》 被引量: 53发表: 1996年 ...