In this regard, we observed that early regulatory genes [Wnt4/Wnt5a/Ctnnb1, Hspa5 (old name grp78/bip) and Nol5 (old name Sik similar protein)] that are known to be elicited by estradiol-17beta (E2) in the mouse uterus without involving ERs as a phase-I response, are intimately ...
This observation highlights the importance of an early HRT intervention for the preven- tion of disc degeneration. In fact, a pos- itive relationship between lumbar inter- vertebral disc height and HRT in post- menopausal women has been reported by Baron and colleagues [1]. When they co...
Other, rapid actions of sex steroids may be cause by direct effects through several possibilities, such as early-intermediate gene activation (e.g., cFOS) or neurotrophin-driven actions (38). Studies mapping estrogen and progestin receptors (PRs) in the brain have shown that ERs and PRs are ...
ER response element (ER) 32-73 Minimal TA promoter (pTA) 102-124 Luciferase reporter gene 156-1818 SV40 late poly(A) signal 1853-2074 SV40 early promoter 2122-2540 Synthetic neomycin phosphotransferase(Neor) coding region 2565-3359 Synthetic poly(A) signal ...
Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women. JAMA.2002;287:2668-2676.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids...
Greene LA, Kaplan DR. Early events in neurotrophin signalling viaTrkand p75 receptors. Curr Opin Neurobiol 1995; 5: 579–587. PubMedCASGoogle Scholar Borasio GD, Markus A, Wittinghofer A, Barde YA, Heumann R. Involvement of Ras p21 in neurotrophin-induced response of sensory, but not sympa...
The significance of the difference between E2B-treated and control group is greater(p < 0.0001) at the early time points(day 5 and 8) than that at the later time points(day 12 and 14)(p < 0.01). It is possible that the effect of E2B is boasted by the inflammatory condition...
Meta-analysis of estrogen response in MCF-7 distinguishes early target genes involved in signaling and cell proliferation from later target genes involved in cell cycle and DNA repair. BMC Syst. Biol. 5 (2011). Muyan, M., Yi, P. & Sathya, G. Fusion estrogen receptor proteins: toward the...
Early events following MPTP exposure, such as increased AP1 transcription, loss of glutathione, and up-regulation of glutaredoxin mRNA is seen only in male mice, indicating that early response to neurotoxic insult does not occur in females. Pretreatment of female mice with ICI 182,780, estrogen ...
to date, have reported that estradiol modulates the expression of a several players in ischemic brain injury including survival factors (Dubal et al., 1999a, b),immediate early genes(Rau et al., 2000),neuropeptides(Dubal et al., 1999a, b), and trophic factors (Böttner et al., 2001...