Estrogen receptors alpha and beta in bone. Bone 2016;87:1305.Khalid AB, Krum SA. Estrogen receptors alpha and beta in bone. Bone. 2016;87:130-5.Khalid, A. B., and Krum, S. A. (2016). Estrogen receptors alpha and beta in bone. Bone 87, 130-135. doi: 10.1016/j.bone....
1.1.1ER function in physiology Estrogen receptorsbelong to the Type I nuclear receptor super family that comprises classicalsteroid receptors. There are two different forms of estrogen receptors, known asestrogen receptoralpha (ERα) and estrogen receptor beta (ERβ). Both receptors can act as tr...
et al. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J. Clin. Invest. 123, 394–404 (2013). Article CAS PubMed Google Scholar Borjesson, A. E. et al. The role of estrogen receptor-α and its activation function-1 for growth plate closure in...
Table 1. Protein, gene and HGNC ID designations for estrogen receptors. ProteinGeneHGNC ID Estrogen receptor alpha (ERα) ESR1 3467 Estrogen receptor beta (ERβ) ESR2 3468 G protein-coupled estrogen receptor 1 (GPER1) GPER1 4485 The expression of ERs has been identified in a wide range ...
Estrogens and their receptors are important in human development, physiology and disease. In this study, we utilized an integrated genome-wide molecular and computational approach to characterize the interaction between the activated estrogen receptor (ER) and the regulatory elements of candidate target ...
Estrogen receptor alpha (ERα) signaling has beneficial skeletal effects in males. ERα signaling also affects other tissues, and to find bone-specific treatments, more knowledge regarding tissue-specific ERα signaling is needed. ERα is subjected to posttranslational modifications, including phosphoryl...
In the semi-fixation distal tibia fracture model, the posterior callus in the sham group showed excessive bone resorption and lower bone mass phenotype compared with the anterior site; a similar trend was not found in the OVX group. At 28 days post fracture, the posterior callus was more mine...
Estrogen receptor-alpha and beta- immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord. Cell Tissue Res. 2001;304(2):193–214. Article CAS PubMed Google Scholar Mangelsdorf DJ, et al. The nuclear receptor superfamily: the second decade. Cell. 1995;83(6):...
Responsible for female sexual characteristics, estrogen stimulates and triggers a response from at least 300 tissues, and may help some types of breast cancer to grow. After menopause, the production of the hormone gradually stops. Mentioned in: Anabolic Steroid Use, Bone Disorder Drugs, ...
alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other ...