The estrogen receptor (ER) assay is widely used to select sensitivity to hormone therapy in patients with breast cancer. Recently, a new form of ER, known as ERβ was identified, the classic form now being denoted ERα. In this investigation, ERα and ERβ were measured at the mRNA ...
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Murphy, L, Cherlet, T, Lewis, A (2003) New insights into estrogen receptor function in human breast cancer. Ann Med 35: pp. 614-631Murphy L, Cherlet T, Lewis A, Banu Y, Watson P (2003) New insights into estogen receptor function in human breast cancer. Ann Med 35:614–631. ...
The authors analyze estrogen receptors in 501 cases of breast cancer and the therapeutic response achieved with treatment of patients who relapsed. The method utilized to determine the presence of estrogen receptor was cytosol protein-counting and Dextran coated charcoal (DCC) saturation analysis. Patien...
Truncated forms of DNA-binding estrogen receptors in human breast cancer. The likelihood a breast cancer will respond to antiestrogen therapy depends on the tumor content of immunoreactive or ligand-binding estrogen receptor (ER)... GK Scott,JL Vigne,CC Benz - 《Journal of Clinical Investigation》...
Estrogen Receptor Alpha in Human Breast Cancer: Occurrence and Significance Estrogens have long been recognized as being important for stimulating the growth of a large proportion of breast cancers. Now it is recognized that estrog... S Ali,RC Coombes - 《Journal of Mammary Gland Biology & Neopl...
Bartels, Matthias Christgen, Angelina Luft, Sascha Persing, Kai Jödecke, Ulrich Lehmann and Hans Kreipe Institute of Pathology, Hannover Medical School, Hannover, Germany Activating mutations of estrogen receptor a gene (ESR1) in breast cancer can cause endocrine resistance of metastatic tumor ...
The pathophysiological role of estrogen receptor variants in human breast cancer The accumulated evidence supports the expression of estrogen receptor variants at both the mRNA and protein levels. The relative level of expression of som... LC Murphy,H Dotzlaw,E Leygue,... - 《Journal of Steroid...
- 《Journal of the National Cancer Institute》 被引量: 343发表: 2007年 BRCA1, a Potential Predictive Biomarker in the Treatment of Breast Cancer To date, estrogen receptor, progestogen receptor, and HER2/neu represent molecular biomarkers currently used in routine clinical practice to aid treatment...
Estrogen and progesterone receptor (ER, PR) signaling control breast development and impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target gene, is debated. We assess the issue in clinically relevant settings by a geneti...