Pacifici R. Mechanisms of estrogen action in bone. In: Bilezikian JP, Raisz LG, Martin TJ, editors. Principles of Bone Biology, 3rd ed. USA: Elsevier Inc; 2008. pp. 921-933.Pacifici R. Mechanism of estrogen action in bone. In: Bilezikian JP, Raisz LG, Rodan GA, editors. ...
The protection of cortical bone mass by estrogens is mediated via ERα, using a non-nucleus-initiated mechanism. By contrast, the AR of mature osteoblasts is indispensable for the maintenance of trabecular bone mass in male mammals, but not required for the anabolic effects of androgens on ...
In the 10 years after menopause, most women undergo lose about 10% to 15% of their peak bone mass. Treatment with estrogen can restore pathologic bone loss induced by menopause, but the mechanism underlying this phenomenon remains unclear. Estrogen deficiency caused by ovariectomy(OVX) results in...
Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Molecular mechanism of action at estrogen receptor α of a new clinically relevant anti-estrogen (GW7604) related to tamoxifen. Endocrinology, 2001, 142(2......
The molecular and genetic mechanisms governing bone cell fate have been intensively studied; however, how the life span of bone cells is determined on a molecular level remains elusive. Estrogen is a key hormone in bone remodeling in several species. The osteoprotective action of estrogen is ...
To increase estrogen levels in people when they are not making enough on their own To treat certain types ofprostate cancerandbreast cancer Estradiol may also be used for other conditions as determined by your healthcare provider. How does estradiol work (mechanism of action)?
Diagram of the mechanism of action of estrogen in lymphangioleiomyomatosis (LAM) MMP2: matrix metalloproteinase 2; MMP9: matrix metalloproteinase 9; NE: neutrophil elastase; HMB-45: melanoma-associated antigens; Hamartin: hamartoma protein; Tuberin: potato globulin Full size image Preclinical investig...
However, the mechanism by which this occurs remains unclear, especially concerning the regulation of osteoclasts, i.e. the bone-resorbing cells. Using a pit assay involving isolated mature osteoclasts from rabbit long bones, we found that estrogen inhibited the bone-resorbing activity in a dose- ...
Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variet
Another mechanism might be estrogen-mediated antagonism on N-methyl-d-aspartate receptors (NMDAR) that were expressed in nephrons [Citation130]. The activation of GPER1 also protected the kidney from IRI through enhancing glomerular endothelial barrier function and regulating the content of NO in ...