ESTROGEN METABOLITE LEVELS AND CANCER DRIVER GENE MUTATIONS IN LUNG CANCER RISK STRATIFICATION AND TREATMENTThe present disclosure provides methods of risk stratification for the development of lung cancer and/or lung cancer recurrence, methods of treatment of a human having lung cancer with therapeutic ...
Estrogen blood levels of women who had breast cancer recurrence were twice as high as those whose breast cancer had not returned, the researchers reported. Rock and team said that the next step is to find lifestyle modification factors that may benefit beast cancer survivors. Exercise has been ...
The article highlights the results of a study which suggest that high levels of estrogen contribute to an increased risk of cancer recurrence, just as they lead to the initial development of breast cancer. The study's lead author, Cheryl L. Rock is a professor in the Department of Family a...
Here, using estrogen-dependent breast cancer cell lines with different p53 status, we show that estrogens, through ERα, influence p53 protein levels and activities. Estrogen dep 展开 关键词: p53 - Estrogen receptor - Breast - Estradiol - Doxorubicin - Apoptosis ...
These may include obesity, aging, certain medications, and an imbalance of sex hormones. In some cases, the cause is not known or cannot be determined. In addition, certain medical conditions such as liver or kidney failure, testicular cancer, and tumors can cause high estrogen levels in men...
Literature in MEDLINE on hormones and breast cancer; Influence of hormonal actions; Information on the positive relationship betwen endogenous hormone levels in postmenopausal women and risk of breast cancer; Reference to the evidence of a causal relationship between female hormones and breast cancer.DOI...
In papillary thyroid carcinomas, these pathways may be activated either by a chromosomal rearrangement of the tyrosine receptor kinase TRKA, by RET/PTC genes, or by a BRAF mutation and, in addition, in females they may be stimulated by high levels of estrogen. Furthermore, estrogen is ...
Fig. 1: TRIM56 relates to poor endocrine treatment outcome and correlates with ER alpha and PR protein levels in human breast cancer samples. Full size image Table 1 Statistics of clinical features and molecular characteristics Full size table ...
IL-24+ cells were arrested in the G1 phase of the cell cycle (Figure 5c), downregulating the hallmark G2M checkpoint gene set, and upregulating the hallmark apoptosis gene set (Table 4). Furthermore, upregulation of IL-24 expression levels and the hallmark ROS pathway after 28-day ...
Excessive estrogen exposure is connected with increased risk of breast cancer and has been shown to promote epithelial-mesenchymal-transition. Malignant cancer cells accumulate changes in cell mechanical and biochemical properties, often leading to cell softening. In this work we have employed atomic forc...