Here, we ablate estrogen receptor alpha (ER伪) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported mouse models. Stereotaxic guided deletion of ER伪 in the ...
And also in men estrogen has some activity it is not a pure female hormone so men do also have estrogen. Not the high concentrations and after menopause women level down to the concentration of estrogen which men have. So then the difference disappears. ...
The mutant S122A ERα mice also display normal mineral density and skeletal architecture of the bones in both females and males [65,66]. The mutant S122A ERα mice show sexually dimorphic tissue-specific genetic effects. The mutant female mice show significantly more fat accumulation, increased ...