Here, we ablate estrogen receptor alpha (ER伪) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported mouse models. Stereotaxic guided deletion of ER伪 in the ...
bones. This preventive activity ofPisidium coreanumagainst bone loss was due to limited osteoclast maturation with reduced osteoclast surface extent in trabecular bone tissue. The formation of large multinucleated osteoclasts in vitro was significantly decreased in response toPisidium coreanum, consistent ...