These genes constitute a minimal gene set required for a living cell. We have constructed a Database of Essential Genes (DEG), which contains all the essential genes that are currently available. The functions encoded by essential genes are considered a foundation of life and therefore are ...
Here we describe the Cluster of Essential Genes (CEG) database, which contains clusters of orthologous essential genes. Based on the size of a cluster, users can easily decide whether an essential gene is conserved in multiple bacterial species or is species-specific. It contains the similarity ...
Using RNAi gene knockout and genetic screens [91,92], 15–30% of the genes in C. elegans were estimated to be essential [93]. The database for essential genes DEG 5.0 [94] includes information on all essential C. elegans genes, which were based on data derived from RNAi experiments [...
Here we propose a new computational algorithm for EG prediction in prokaryotes with an online database (ePath) for quick access to the EG prediction results of over 4,000 prokaryotes (https://www.pubapps.vcu.edu/epath/). In ePath, gene essentiality is linked to biological functions ...
These genes constitute a minimal gene set required for a living cell. We have constructed a Database of Essential Genes (DEG), which contains all the essential genes that are currently available. The functions encoded by essential genes are considered a foundation of life and therefore are ...
We identified 6 datasets in the GEO database with RNA-seq from brain tissue of several case–control studies, including AD, ALS, ASD, HD, PD, and SCZ. We initially downloaded the raw gene expression data and then used the R package DESeq2 to normalize them, or downloaded the DESeq2 ...
The gene embedding vectors for essential and non-essential genes have been deposited into the Data directory. These embedding vectors were generated from the transcriptome data of either pan-cancer or specific cancer types (COAD, CESC and GBM) using unsupervised collaborative embedding. The transcriptom...
Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis16, 146–147, https://doi.org/10.1016/s1473-3099(15)00533-2 (2016). Article PubMed Google Scholar Hu, B. et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin...
Phenotypes are variable within species, with high phenotypic variation in the fitness and cell morphology of natural yeast strains due to genetic variation. A gene deletion collection of yeast laboratory strains also contains phenotypic variations, demon
A new essential gene of Saccharomyces cerevisiae was found upstream of GCR1. Its cloning and sequencing predict a 280 amino acid protein (32 577 Da). The predicted protein is fairly hydrophobic, and a search of the database did not identify any homologous proteins. A LEU2 disruption at codon...