Escherichia coli Nissle 1917Bacterial ghostsInflammatory bowel diseaseZebrafishDrug delivery systemEscherichia coli Nissle 1917 (EcN) has become a research hotspot in inflammatory bowel disease (IBD). It has a strong targeting effect on the colon, and has some therapeutic effect on inflammatory bowel ...
edu. cn 收稿日期:2018~08~20抗肿瘤工程菌 EscherichiacoliNissle1917发酵培养基优化及微胶囊制备吴柳娟ꎬ 李 躺ꎬ 莫相涛ꎬ 胡益波ꎬ 丁学知ꎬ 夏立秋 ∗(湖南师范大学 生命科学学院ꎬ湖南 长沙 410081)摘 要 为了获得高活力抗肿瘤工程菌 EscherichiacoliNissle1917(EcNA)微胶囊制剂ꎬ对 EcNA 进行...
Escherichia coli Nissle 1917 (EcN) is a Gram-negative bacterium that is used to treat inflammatory bowel diseases. The probiotic character of EcN is not well-understood, but its ability to produce secondary metabolites plays an important role in its activity. The EcN genome encodes for an aryl...
Escherichia coliNissle 1917 (EcN) is the active component of Mutaflor® (Ardeypharm GmbH, Herdecke, Germany), a probiotic drug licensed in several countries for the treatment of multiple intestinal disorders10. Clinical trials have shown EcN to be effective for the treatment of abdominal pain in...
coli Nissle 1917 strains on growth and stx gene expression of EHEC O104:H4 and O157:H7 using a quanti- tative real time-PCR approach. The influence of probiotic EcN on Shiga toxin amount and cytotoxicity from sterile supernatants of EHEC was also investigated. Materials and methods ...
Escherichia coli Nissle 1917 (EcN) is one of the most widely used probiotics to treat gastrointestinal diseases. Recently, many studies have engineered EcN to release therapeutic proteins to treat specific diseases. However, because EcN exhibits intestinal metabolic activities, it is difficult to ...
Escherichia coli Nissle 1917 (Mutaflor): new insights into an old probiotic bacterium. Escherichia coli Nissle 1917 (Mutaflor): new insights into an old probiotic bacterium. Dig Dis 2011; 29:600-7.C. A. Jacobi and P. Malfertheiner, ... Christoph,A,Jacobi,... - 《Digestive Diseases》 ...
Escherichia coli is the most well-studied model prokaryote and has become an indispensable host for the biotechnological production of proteins and biochemicals. In particular, the probiotic status of one E. coli strain, E. coli Nissle 1917 (EcN) has helped it become a new favorite amongst synth...
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The probiotic Escherichia coli Nissle 1917 (EcN) has long been used for treating intestinal diseases. Here, we demonstrate frequent transfer of ARGs into EcN both in vitro and in vivo, raising concerns about its potential risk of accumulating antibiotic resistance. Given that no CRISPR-Cas system...