In these more recently appreciated nonhormonal roles, locally-produced EPO signals through a different receptor isoform and is a major molecular component of the injury response, in which it counteracts the effects of pro-inflammatory cytokines. Acutely, EPO prevents programmed cell death and reduces ...
Epo receptor (EpoR) is a membrane receptor that belongs to the cytokine class I receptor superfamily, which is characterized by a tryptophan–serine tandem motif (WS-x-WS), a single transmembrane domain and a non-active cytosolic tail [14]. ...
Epo stimulates proliferation and differentiation of erythroid precursor cells, but may also bind to and exert some additional effects in nonhemopoietic tissues. It is mainly produced in the kidneys and to minor extents also in the liver and in the brain. The plasma concentration of erthyropoiet...
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1/3 REVIEW Open Access Erythropoietin (EPO) in acute kidney injury Elizabeth Moore, Rinaldo Bellomo* Abstract Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow...
Erythropoietin (EPO), produced in the kidney, is the hormone responsible for production and regulation of red blood cells [1]. The recombinant product (rHuEPO) is available for treatment of anemia secondary to renal failure [2], as well as other causes such as solid and hematologic neoplasms ...
Erythropoietin (EPO) is a 165 amino acid glycoprotein hormone (30.4 kDa) member of the type 1 cytokine superfamily that is produced primarily by renal cortical and outer medullary type 1 fibroblasts [Patel, N. S. A.Queen Mary University of London Centre for Translational Medicine and ...
Erythropoietin (Epo), which is produced by the kidney in the adult and by the liver in the fetus, increases red blood cells by supporting the survival of e... SASAKI, Ryuzo,MASUDA, Seiji,NAGAO, Masaya - 《Journal of the Agricultural Chemical Society of Japan》 被引量: 428发表: 2000年 ...
Erythropoietin (Ep) is produced mainly by the liver and spleen during fetal and neonatal periods and by the kidney during adolescent and adult life. The liver is also an important extrarenal producer of Ep in the hypoxic, anephric adult ... BA Naughton,JA Piliero,RE Kruger,... - 《America...
In the brain, EPO is produced by astrocytes in response to hypoxia and mediates paracrine and autocrine survival pathways, reducing cell death in the ischaemic penum- bra. Exogenous administration of EPO attenuates cell death in ischaemic brain and spinal cord injury, associ- ated with functional ...