Recombinant Human Erythropoietin-alpha Fc/Chimera 供应商 ProSpec 产品货号 CYT-325 产品报价 ￥询价/10ug ￥1mg ￥2ug 产品说明书 点击查看 购买方式 在线支付宝及网银支付、支票、现金、电汇,或拨打全国免费服务电话4006800868与我们联系. 产品新闻 背景资料 ...
glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO mammals are maintained primarily by the kidneys, whereas levels in fetal or ...
T. Erythropoietin reduces fat mass in female mice lacking estrogen receptor alpha. Mol. Metab. 45, 101142 (2021). Article PubMed CAS Google Scholar Heinicke, K. et al. Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular ...
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Requirement for p38α in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102:221-231.Tamura, K., Sudo, T., Senftleben, U... K Tamura,T Sudo,U Senftleben,... -...
Thus, from a half-life of 19.4 ± 2.4 hours for erythropoietin alpha [1] and 24.2 ± 2.6 hours for erythropoietin beta [2] after subcutaneous administration, and a recommendation to administer these agents up to three times per week, we are now using compounds such as darbepoetin [3] -...
Transcriptional signals controlling mitochondrial biogenesis and dynamics were altered with EPO-associated increases in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), mitofusin 1 (MFN1), mitofusin 2 (MFN2), and DRP1-DNM1. Thus, EPO-mediated activation of Erk1/2 and ...
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Salceda S, Caro J: Hypoxia-Inducible Factor 1alpha (HIF-1alpha) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System Under Normoxic Conditions. Its Stabilization by Hypoxia Depends on Redox-Induced Changes. J Biol Chem. 1997, 272: 22642-22647. 10.1074/jbc.272.36.22642. Article CAS ...
Thus, from a half-life of 19.4 ± 2.4 hours for erythropoietin alpha [1] and 24.2 ± 2.6 hours for erythropoietin beta [2] after subcutaneous administration, and a recommendation to administer these agents up to three times per week, we are now using compounds such as darbepoetin [3] -...
In addition, EPO has been shown to reduce the expression of proinflammatory mediators, TNF-alpha and IL-2, in IR renal injury and reverse the effect of endotoxin on the antioxidant, renal superoxide dismutase (SOD). These anti-inflammatory properties of EPO also suggest involvement of the NF-...