The two erythropoietin products used were human recombinant erythropoietin alpha (Tropin) and erythropoietin beta (Recormon). Both groups were age-matched, BMI, eGFR, gender, and comorbidities like diabetes and hypertension were indifferent. The comparative analysis was performed after the completion of ...
alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice. J Clin Invest 2008;118:965–974. 34. Desmoulie`re A, Geinoz A, Gabbiani F, et al. Transforming growth factor-beta 1 induces a-smooth muscle actin expression in granulation tissue myofibroblasts ...
Erythropoietin (EPO) plays a key role in energy metabolism, with EPO receptor (EpoR) expression in white adipose tissue (WAT) mediating its metabolic activity. Here, we show that male mice lacking EpoR in adipose tissue exhibit increased fat mass and sus
In addition, EPO has been shown to reduce the expression of proinflammatory mediators, TNF-alpha and IL-2, in IR renal injury and reverse the effect of endotoxin on the antioxidant, renal superoxide dismutase (SOD). These anti-inflammatory properties of EPO also suggest involvement of the NF-...
(e.g. HIF-1 alpha and beta and HIF-2), hormones (e.g., insulin, growth hormone (GH), CRH, Leptin, Prolactin and TSH), angiogenic factors (e.g., angiogenin and angiopoietin), coagulation and anticoagulation factors [e.g., Factor I, Factor XIII, tissue factor, calcium, vWF, protein...
Thus, from a half-life of 19.4 ± 2.4 hours for erythropoietin alpha [1] and 24.2 ± 2.6 hours for erythropoietin beta [2] after subcutaneous administration, and a recommendation to administer these agents up to three times per week, we are now using compounds such as darbepoetin [3] -...
p < 0.05 was considered to indicate a statistically significant difference. Spearman rank correlation was applied to assess the correlation among the protein level of EPO, EPOR, HIF-1α, and Ki-67. Results Expression of EPO and EPOR is up-regulated in human HCC tissue Twenty-eight HCC ...
Thus, from a half-life of 19.4 ± 2.4 hours for erythropoietin alpha [1] and 24.2 ± 2.6 hours for erythropoietin beta [2] after subcutaneous administration, and a recommendation to administer these agents up to three times per week, we are now using compounds such as darbepoetin [3] -...
(Fig.4a). However, there was no significant difference in the number of IBA1/Pu.1 positive cells between laser-induced CNV of hMtEPOR and mWtEPOR (Fig.4b), despite increased CNV volumes in the hMtEPOR animals (p = 0.04; Fig.4c). Of note, volume measurements were similar for ...
Transcriptional signals controlling mitochondrial biogenesis and dynamics were altered with EPO-associated increases in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), mitofusin 1 (MFN1), mitofusin 2 (MFN2), and DRP1-DNM1. Thus, EPO-mediated activation of Erk1/2 and ...