The main reason is that, nowadays, MCTD is recognized as a distinct entity with unique clinical features, therapeutic response, and prognosis. MCTD is characterized by the concomitant occurrence of clinical symptoms of different rheumatic disorders without meeting the clear diagnostic criteria for these...
In the SLE group, however, when we associate with specific cognitive domains, SLEDAI was negatively associated with semantic fluency (SVF, p = 0.031) and inhibitory control/selective attention (ST points, p = 0.032), meaning the higher score was correlated with poor performance on ...
The present invention includes a system and a method to analyze samples for the prognosis, diagnosis and monitoring of disease progression of Systemic Lupus Erythematosus (SLE) using multivariate gene expression analysis. The gene expression differences that remain can be attributed with a high degree ...
Time in remission and cumulative glucocorticoid exposure are the most important factors for prognosis. Therefore, timely identification of SLE clinical patterns may help tailor the therapeutic intervention to the disease course. Late-onset SLE is rare but more often associated with delayed diagnosis and...
Thus, the invention provides biomarkers and biomarker signatures for determining a systemic lupus erythematosus-associated disease state in a subject. By “systemic lupus erythematosus-associated disease state” we include the diagnosis, prognosis and/or characterisation of phenotypic subtype of SLE in the...
While lupus is a chronic illness, it is characterized by periods when the disease activity is minimal or absent (remission) and when it is active (relapse or flare). The outlook (prognosis) for patients with lupus today is much better than years ago because of greater awareness and more acc...
Lupus Prognosis With early aggressive treatments, most patients with lupus carry on with normal lives and are living longer than in the past. The keys to the outlook for each person affected by lupus is the severity of disease and whether or not vital organs are affected. The prognosis for ...
would thus be essential to therapeutic regime choice and treatment modifications, as well as prognosis (2-4). Currently, disease activity is assessed using indices, such as SLEDAI-2K, which is based on 24 descriptors in 9 organs (studied over 10 or 30 days) (5). Monitoring of the renal ...