【摘要】目的 探讨阿克替苷(ACT)通过调控ERK1/2通路抑制人肝癌HCCLM3细胞上皮间质转化(EMT)的作用及其机制。方法 CCK-8法检测肝癌细胞的增殖能力;划痕实验和Transwell实验检测肝癌细胞侵袭及迁移能力;实时定量PCR和蛋白质印迹实验检测ACT对ERK1/2...
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5. Ullah, et al. RAF-MEK-ERK pathway in cancer evolution and treatment. Semin Cancer Biol, 2022.https://doi.org/10.1016/j.semcancer.2021.05.010 6. Wen, X., Jiao, L., & Tan, H. MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration. Int J Mol Sci, 2022.https:...
M MiyakeS GoodisonA LawtonE Gomes-GiacoiaC J RosserOncogenethe ERK1/2 pathway, which causes increased transcriptional activity of PRL-stimulated transcriptionthe ERK pathway, because there are specific inhibitors of
AIBP通过ERK1/2-MAPK信号通路促进肝癌细胞增殖和迁移(AIBP promotes cell proliferation and migration through the ERK1/2-MAPK signaling pathway in hepatocellular carcinoma) 内容亮点 在癌症相关死亡率上,肝细胞癌在全球排名第三,目前其诊断和治疗仍较困难。高密度脂蛋白(HDL)的主要载脂蛋白是载脂蛋白a - i结合...
pressure,throughactivatingERK1/2kinaseinatrialfibroblasts,eventuallycontributetoAF. Keywords:Atrialfibrillation;hypertension;Piezo1;ERK1/2pathway;atrialfibrosis IV 目录 摘要I AbstractIII 目录V 1心房纤维化与AF1 2高血压与AF2 2.1高血压与心房纤维化3 2.2机械应力导致心房重构的相关机制4 3机械敏感离子通道Piezo1...
A. M.; Roix, J. J.; Hale, M.; Boucher, D. M.; Sorrell, D. A.; Martinez-Botella, G.; et al. Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib). Mol. Cancer Ther. 2017, 6, 2351‒23...
参考文献:Tang Y, Fan Y, Luo Q, Song G. Pressure Loading Induces DNA Damage in Human Hepatocyte Line L02 Cells via the ERK1/2-Dicer Signaling Pathway. Int J Mol Sci. 2022 May 10;23(10):5342. doi: 10.3390/...
Phospho-Erk1/2 Pathway Sampler Kit 规格 1 Kit 货号 GOYK98064 一抗和二坑的区别: *抗体就是平常所说的抗体,即能和抗原特异性结合。 *抗体是能和抗体结合的,即抗体的抗体。主要用于检测抗体的存在。 一抗是针对抗原的抗体,二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说,抗原进入...