ERK1/2信号通路通过P300调控ATF2 K357ac促进胰腺癌发生发展(The Ras-ERK signaling pathway regulates acetylated activating transcription factor 2 via p300 in pancreatic cancer cells) 内容亮点 据报道,Ras-细胞外信号调节激酶(Ras-...
本文引用格式: Shenjian LUO, Zhi YANG, Ruxin CHEN, Danming YOU, Fei TENG, Youwen YUAN, Wenhui LIU, Jin LI, Huijie ZHANG. Cytokine receptor-like factor 1 (CRLF1) promotes cardiac fibrosis via ERK1/2 signaling pa...
ERK1/2 信号分子在压力负荷下调节肝细胞中的 Dicer 表达水平和 DNA 损伤 ERK1/2 调节多种细胞生物学过程以响应正常和病理条件下的应激,例如增殖、分化、凋亡和关键信号通路。据报道,磷酸化 ERK1/2(p-ERK1/2)会因机械刺激而发生改变。此外,p-ERK1/2 调节 Dicer的转录水平。因此,研究推测压力可能通过 ERK1/...
Tumor necrosis factor alpha promotes apoptosis in long bone-like cells via ERK1/2 signaling pathway Shi Fangfu, Cui Hongwang, Sun Bo PDF 470 摘要/Abstract 摘要: 文题释义: 肿瘤坏死因子α:是一种主要由巨噬细胞和单核细胞产生的促炎细胞因子,并参与正常炎症反应和免疫反应。
Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib). Mol. Cancer Ther. 2017, 6, 2351‒2363. Sigaud, R.; Rösch, L.; Gatzweiler, C.; Benzel, J.; von Soosten, L.; Peterziel, H.; Selt, ...
A. M.; Roix, J. J.; Hale, M.; Boucher, D. M.; Sorrell, D. A.; Martinez-Botella, G.; et al. Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib). Mol. Cancer Ther. 2017, 6, 2351‒23...
AIBP通过ERK1/2-MAPK信号通路促进肝癌细胞增殖和迁移(AIBP promotes cell proliferation and migration through the ERK1/2-MAPK signaling pathway in hepatocellular carcinoma) 内容亮点 在癌症相关死亡率上,肝细胞癌在全球排名第三,目前其诊断和治疗仍较困难。高密度脂蛋白(HDL)的主要载脂蛋白是载脂蛋白a - i结合...
In this chapter, we review the role of ERK1/2 MAP kinase signaling in the pathogenesis of tumor metastasis.doi:10.1007/978-90-481-9522-0_3Laure Voisin∗Stéphanie Duhamel∗Sylvain MelocheSpringer NetherlandsThe ERK1/2 MAP kinase signaling p Pathway in tumor progression and metastasis. Voisin...
importantroleintheformationofcataractandpromotesthelensepitheliumcellsproliferationanddiffractiontofibroblastcells,butthesignalpathwayremainspoorlyunderstood.OBJECTIVE:ToinvestigatetheroleofERK1/2signalingpathwayinbFGF-inducedtheexpressionofcyclooxygenase-2(COX-2)inhumanlensepithelialcelllineHLB-C3.METHODS:Humanlens...
The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli, including mitogens, growth factors, and cytokines (1-3), and research investigators consider it an important target in the diagnosis and treatment of cancer (4). Upon ...