Treatment of MM cell lines with the ferroptosis inhibitor erastin resulted lower expression of TXN in both mRNA level and protein level. Using Jasper database, we locked several TFs of TXN, and ChIP analyse sho
(C) GC cells were treated with erastin (E, 10 μg/ml) and with or without Z-VAD-FMK (apoptosis inhibitor), necrostatin (necroptosis inhibitor), 3-methyladenine (3-MA, autophagy inhibitor), and ferrostatin-1 or liproxstatin-1 (ferroptosis inhibitors) for 24 hours. Cell viability was assaye...
Erastin is a ferroptosis activator. ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂的供应商,致力于为广大科研、商业实验室的科学研究者提供高品质的产品与技术服务,不断促进生命科学领域的新技术发展。 公司简介 ChemeGen 作为*的抑制剂、激动剂及新型生物科学试剂等系列产品的供应商及制造商,致力于为广大科...
Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 M).[2] It induces cell death in HAP1 cells when used at a concentration of 5 M, an effect that can be blocked...
whileATF3knockout suppressed ferroptosis induced by the GPX4 inhibitor RSL3—a type 2 FIN—as well (Supplementary Fig.S3A,S3B). However, ATF3 had a negligible effect on cell sensitivity to FIN56, a type 3 FIN, which induces ferroptosis by depleting CoQ10 and GPX4 [7,38] (Supplementary ...
Of note, ATF3 expression promoted, while ATF3 knockout suppressed ferroptosis induced by the GPX4 inhibitor RSL3—a type 2 FIN—as well (Supplementary Fig. S3A, S3B). However, ATF3 had a negligible effect on cell sensitivity to FIN56, a type 3 FIN, which induces fer- roptosis by ...
储存:Store at -20°,Cprotect from light 库存:现货 Background Erastin2 is a potent system xc- inhibitor and ferroptosis-inducing agent[1]. Erastin2 (5μM, 24h) significantly inhibited the activity of human HAP1 haploid cells, and that erastin2-induced cell death was inhibited by co-treatmen...
2023; published online March 30, 2023 Abstract Objectives: CDGSH iron sulfur domain 2 (CISD2) is essential to maintain iron (Fe) and reactive oxygen species (ROS) ho- meostasis, and ferroptosis suppressor protein 1 (FSP1) can protect cells from ferroptosis by inhibiting lipid peroxida- tion...
CDGSH iron sulfur domain 2 (CISD2) is essential to maintain iron (Fe) and reactive oxygen species (ROS) homeostasis, and ferroptosis suppressor protein 1 (FSP1) can protect cells from ferroptosis by inhibiting lipid peroxidation. Here, we investigate the role and potential mechanism of CISD2 an...
Osteoarthritis (OA) is associated with ferroptosis, a newly discovered form of programmed cell death associated with lipid peroxidation. Curcumin, the main monomer component in turmeric rhizomes, possesses antioxidant and anti-ferroptosis properties, but its effect on ferroptosis in chondrocytes of OA is...