《Erastin联合紫草素通过调节EMT和凋亡对结直肠癌细胞的抑制作用及机制研究》一、引言结直肠癌(ColorectalCancer,CRC)是世界上较为常见的消化道恶性肿瘤之一,其发生和进展受多种内外因素的影响。在目前的治疗策略中,药物治疗、特别是小分子药物的开发成为了抗肿瘤的重要方向。Erastin作为一种具有潜力的肿瘤治疗药物,与...
本研究表明,Erastin联合紫草素能显著抑制结直肠癌细胞的活力,这可能与它们对EMT和凋亡的调节作用有关。联合使用Erastin和紫草素能降低Vimentin等间质标志物的表达,增加E-cadherin等上皮标志物的表达,从而抑制结直肠癌细胞的EMT过程。此外,联合使用Erastin和紫草素还能诱导结直肠癌细胞的凋亡,这可能与Bcl-2等抗凋亡蛋白的...
Phosphorylating SOX2 contributes to preservation of stem-cell-like cells [31], while stabilizing YBX1 promotes EMT, formation of stem cells, and resistance to chemotherapy [32]. AURKA phosphorylates LDHB at Ser162, which enhances its activity in converting pyruvate to lactate, subsequently promoting ...
2A). It is generally accepted that the redox imbalance in cancer cells leads to recurrence, drug resistance, and metastasis [32], which are typical characteristics of the epithelial–mesenchymal transition (EMT). Accordingly, it is assumed that the lower levels of the reduced form of GSH ...
CDGSH iron sulfur domain 2 activates proliferation and EMT of pancreatic cancer cells via Wnt/β-catenin pathway and has prognostic value in human pancreatic cancer. Oncol Res 2017;25:605–15, https://doi.org/10.3727/096504016x14767450526417.Search in Google Scholar 27. Zhu, QQ, Tian, L, Li...
Q. et al. circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis. Cell Death Dis 12, 168 (2021). Article PubMed PubMed Central CAS Google Scholar Saini, J. & Sharma, P. K. Clinical, prognostic and therapeutic significance of heat ...
CDGSH iron sulfur domain 2 activates proliferation and EMT of pancreatic cancer cells via Wnt/β-catenin pathway and has prognostic value in human pancreatic cancer. Oncol Res 2017;25:605–15, . Google Scholar Y Yang, YS Bai, Q Wang CDGSH iron sulfur domain 2 activates proliferation and EMT...
[4,5]. Therefore, CXCL8-CXCR1/CXCR2 signaling pathways through autocrine and paracrine mechanisms form complex crosstalk among the cells in the ovarian tumor microenvironment. For example, CXCL8 initiates the epithelial-mesenchymal transition (EMT) program and activates Wnt/beta-catenin signaling in ...
For exam- ple, CXCL8 initiates the epithelial-mesenchymal transition (EMT) program and activates Wnt/beta-catenin signaling in ovarian cancer cells, promoting cancer cell invasion and metastasis [5]. CXCL8 can recruit tumor-associated neutrophils, which partly impair the Pharmaceuticals 2023, 16, ...
Journal of Clinical Medicine Article Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-κB Pathway Byung Moo Oh 1,†, Seon-Jin Lee 2,3,†, Gyoung Lim Park 2,3, Yo Sep Hwang 1,3, Jeewon Lim 1,3, Eun Sun Park 1,3, Kyung Ho Lee 4, Bo ...