Ferrostatin-1 (Fer-1)_Erastin诱导的Ferroptosis抑制剂_347174-05-4_Apexbio
目的 研究Erastin对人神经母细胞瘤细胞(SH-SY5Y)的损伤作用及Ferrostatin-1(Fer-1)和Deferoxamine(DFO)对细胞损伤的保护效果,为Fer-1和DFO应用于神经退行性疾病提供依据.方法 将SH-SY5Y细胞分为溶剂对照组(DMSO),Erastin组(10μmol/L),Fer-1组(10μmol/L),DFO组(100μmol/L),Erastin+Fer-1组(10μmol/L...
摘要 目的 研究Erastin对人神经母细胞瘤细胞(SH-SY5Y)的损伤作用及Ferrostatin-1(Fer-1)和Deferoxamine(DFO)对细胞损伤的保护效果,为Fer-1和DFO应用于神经退行性疾病提供依据...展开更多 Objective To investigate the damage effect of Erastin on human neuroblastoma cells(SH-SY5Y) and the protective effect of...
产品说明书 化学性质 产品名: Ferrostatin-1 (Fer-1) 修订日期: 6/30/2016 产品名: Cas No.: 分子量: 分子式: 化学名: SMILES: 溶解性: 储存条件: 一般建议: 运输条件: Ferrostatin-1 (Fer-1) 347174-05-4 262.35 C15H22N2O2 NC1=C(NC2CCCCC2)C=CC(C(OCC)=O)=C1 >9.8mg/mL in DMSO ...
In corroboration, the use of ferroptosis inhibitor, ferrostatin-1 (Fer-1), was found to enhance the cell viability of ICCs and prevent them from ferroptosis as well as improve its function. Mechanistically, the erastin-induced ferroptosis in ICCs was probably mediated via activation of JNK/P38/...
Similarly, elevated levels of LDH and MDA were observed in erastin-treated CH157MN cells, which were attenuated by Fer-1. Conversely, no alterations were detected in CH157MN cells overexpressing wild-type AURKA (Fig. S3D and E). We conducted additional experiments to validate the suppression ...
(D, E) Flow cytometry for Annexin V and 7-AAD 24 h after 40 μM erastin treatment with or without ferrostatin (Fer-1) pretreatment (D) or Z-VAD (E). (F) Fold ratio of GSH/GSSG 24 h after treatment with 40 μM erastin in A549 or TD cells. (G) Relative ratio of the ...